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Introduction

365 330 General Pathology. Introduction. Darunee Jintakanon Department of Pathology Faculty of Medicine, KKU. Pathology คือ อะไร ? ทำไมต้องเรียน ? เรียนอย่างไร ? ต้องการพื้นฐานความรู้ใดบ้าง จะได้ใช้วิชานี้เมื่อไร ? อย่างไร ?. Pathology คือ อะไร ?. Pathology = Pathos + Logos

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Introduction

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  1. 365 330 General Pathology Introduction Darunee Jintakanon Department of Pathology Faculty of Medicine, KKU

  2. Pathology คือ อะไร? • ทำไมต้องเรียน? • เรียนอย่างไร? • ต้องการพื้นฐานความรู้ใดบ้าง • จะได้ใช้วิชานี้เมื่อไร? อย่างไร?

  3. Pathology คือ อะไร? Pathology = Pathos + Logos Suffering Study Study of Disease พยาธิวิทยา

  4. ทำไมต้องเรียน? • จะได้ใช้วิชานี้เมื่อไร? diagnosis

  5. Abnormal stage of body  Disease • Disorderly function (show off as abnormal sign and symptom) of organ system of body (cell, tissue, organ)

  6. Ascites, cachexia, cough, dysphagia, fever, gynecomastia, hemoptysis, hepatomegaly, splenomegaly, icterus, lymphadenopathy, palmar erythema • Sign = objective symptom of disease • Symptom = subjective sign of disease • Chest pain, dizziness, loss of appetite, weakness, numbness, headache, toothache

  7. The concept of disease Hypertrophy /hyperplasia Atrophy Metaplasia Change with adaptation Cell Tissue Organ Environmental factors Lesion Structural change Inability to adapt Injury Death Signs Functional change Symptoms Genetic factors

  8. The general main causes of disease i ii Congenital Diseases Acquired Diseases Inflammation: appendicitis, TB Hemodynamicdisorder : shock, MI Growth disorders Neoplasia: lung CA Injury, disordered repair: fracture, aspirin induced PU Genetic Non genetic Non neoplastic: BPH Immune disorder: AIDS, Graves’ disease Inherited : cystic fibrosis Environmental : rubella assoc mal- Metabolic disorders: DM Spontaneous : Down’s syndrome Accidental : cerebral palsy ~ birth hypoxia Degeneration: osteoarthritis * Familial diseases * Abnormal Growth & Development Cushing’s syndrome ~ X steroids Iatrogenic disease Aplastic anemia ~ chloramphenicol

  9. Scope of Pathology Anatomical Pathology Clinical Pathology • clinical chemistry • clinical hematology/blood banking • clinical microbiology • surgicalpathology • cytopathology • forensicpathology • Oral and maxillofacial pathology Pathologists ~ medicaltechnologists Veterinarypathology is concerned with animal disease Phytopathology is the study of plant diseases.

  10. A combinationboth anatomical and clinical pathology is known as general pathology

  11. General pathology • also called investigative pathology, experimental pathology or theoretical pathology • is a broad and complex scientific field which seeks to understand the mechanisms of injury to cells and tissues, as well as the body's means of responding to and repairing injury

  12. THEORETICAL STUDY เรียนอย่างไร? Main object is to know the nature of DISEASE by study as the following :- 1. Etiology ( causes of diseases ) 2. Pathogenesis (mechanism of diseases) 3. Pathological changes : structural change  Lesion

  13. THEORETICAL STUDY 4. Clinical feature : functional & structural changes symptoms & signs of patients 5. Complication 6. Prognosis ( prediction the future of victim)

  14. Etiology S.aureus HBV Smoking , Polycyclic AHC Pathogenesis Acute inflammation Immune reaction to virus infected cells Increased renin production Genetic mutation Morphological and functional features Boil Cirrhosis Lung cancer High BP Complications & sequelae Liver failure Cerebral hemorrhage Septicemia Metastasis

  15. เรียนอย่างไร? TACTICAL STUDY ศึกษาโดย “เปรียบเทียบ” ระหว่างสิ่งปกติ กับ สิ่งซึ่งผิดปกติไปจากธรรมชาติของมนุษย์ เปรียบเทียบสิ่งเดียวกัน ชนิดเดียวกันในเรื่องโครงสร้าง และ หน้าที่การทำงาน ของอวัยวะ เนื้อเยื่อ และเซลล์ นั้น

  16. ตัวอย่างการเปรียบเทียบตัวอย่างการเปรียบเทียบ Structure Normal squamous cell VS abnormal squamous cell Function of organ, tissue, cell Normal blood sugar VS abnormal blood sugar

  17. ตัวอย่างการเปรียบเทียบตัวอย่างการเปรียบเทียบ

  18. ตัวอย่างการเปรียบเทียบตัวอย่างการเปรียบเทียบ

  19. Techniques of Pathology Biochemical Microbiological Hematological Cell/ tissue culture

  20. Learning objective 1. The meaning of pathology and scope of pathology. 2. How to study the pathology? 3. Techniques of Pathology 4. The general main causes of disease

  21. REFERENCES 1. General and systematic Pathology, 4th edition, edited by J.C.E.Underwood, “Introduction to Pathology” 2. Concise Pathology, 3rd edition, edited by P. Chandrasoma ; C.R. Taylor, Introduction : The Discipline of Pathology, pp xiii – xiv 3. Robbins and Cotran Pathologic Basis of Disease, 7th edition, edited by Kumar; Abbas; Fausto; “Introduction to Pathology” pp 4

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