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Center for Homogeneous DNA Analysis

Center for Homogeneous DNA Analysis. University of Utah Departments of Pathology, Mathematics, and Engineering. What We Do And Why. High Resolution Melting Analysis We Watch DNA Unwind Very Carefully Mutation Scanning, Genotyping, Transplant Compatibility Proprietary Technology.

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Center for Homogeneous DNA Analysis

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  1. Center for Homogeneous DNA Analysis University of Utah Departments of Pathology, Mathematics, and Engineering

  2. What We Do And Why • High Resolution Melting Analysis • We Watch DNA Unwind Very Carefully • Mutation Scanning, Genotyping, Transplant Compatibility • Proprietary Technology

  3. What’s So Special? • Faster, More Economical • Minutes vs. Hours • Pennies vs. Dollars • We Do It Automatically Without Opening The PCR Tube - Simpler • Highly Accurate • Detects Single Base Changes In 1000bps

  4. High-Resolution Melting Analysis: Hardware, Reagents, Software LightScanner™

  5. A Medically Important Mutation - 3000 tests/mo in UT “Auto Call” of Plate Using Unbiased Hierarchal Clustering Temperature

  6. CEPH Family UT1331 2, 9, 10, 13 8 3, 5, 6, 11, 12 1, 4, 7 Transplant Matching

  7. Transplant Matching • Traditionally done by sequencing or serology: • $1,200 per family member ($15,600 for UT1331 family) • High-resolution melting analysis: • can be priced as low as $100 per family member ($1,300) • Transplants: 50,000/year U.S.

  8. Current Status • Scanning Technology • Partly Licensed to Utah Company • Product Sales: $600,000 first year • Enthusiastic customer feedback (e.g. Mayo Clinic) • Twelve new jobs • Two Fast Track STTRs granted • $1.7M matching funds • For advanced instrumentation

  9. The Vision • Make DNA screening routine for: • Research (individual labs ~ core labs) • Gene-mapping organizations • Clinical reference labs • Eventually, hospital STAT labs • Displace 95% of DNA sequencing market

  10. Market Size & Forecast • 42 million assays annually • $10M using melting analysis • Displaces $150M using sequencing • 12,000 instruments, software, $195M • Reagents • Developing market • HLA, 50,000 transplants (US) • Molecular tests growing at +15%

  11. Future Reality • DNA diagnosis at your doctor’s office. • PCR in 15 min • Melting in 2 min • Immediate automated analysis • PCR and melting on a chip • 1 32  384  384,000 • Whole genome analysis (30,000 genes)

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