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Patrick J. Stover, PhD.: Cornell University (CU) Marie A. Caudill. PhD, RD: CU

Genetic and Epigenetic Contributions to Human Nutrition and Health: Managing Genome-Diet Interactions. Patrick J. Stover, PhD.: Cornell University (CU) Marie A. Caudill. PhD, RD: CU. JOURNAL OF THE AMERICAN DIETETIC ASSOCIATION. Stover, P, et al. J Am Diet Assoc. 108 (9), Sep. 2008.

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Patrick J. Stover, PhD.: Cornell University (CU) Marie A. Caudill. PhD, RD: CU

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  1. Genetic and Epigenetic Contributions to Human Nutrition and Health: Managing Genome-Diet Interactions Patrick J. Stover, PhD.: Cornell University (CU) Marie A. Caudill. PhD, RD: CU JOURNAL OF THEAMERICAN DIETETICASSOCIATION Stover, P, et al. J Am Diet Assoc. 108 (9), Sep. 2008

  2. Genetic and Epigenetic Contributions to Human Nutrition and Health: Managing Genome-Diet Interactions Nutrient-genome interactions. Nutrient Absorption Nutrient Utilization Food/Nutrient Tolerance Nutrient Requirement Food/Nutrient Nutrigenomics Nutrigenetics Genome Evolution/Selection Genome Mutation Rate In-utero Genome Viability Genome Programming Gene Expression Genetic Variation JOURNAL OF THEAMERICAN DIETETICASSOCIATION Stover, P, et al. J Am Diet Assoc. 108 (9), Sep. 2008

  3. Genetic and Epigenetic Contributions to Human Nutrition and Health: Managing Genome-Diet Interactions The fetal origins of disease hypothesis. Early Nutrition Experiences Malnutrition Sub-optimal-nutrient Environments Risk Phenotype Obesity Hypertension Insulin Resistance Adult Onset Disease CVD Diabetes Metabolic Syndrome “Program” “Imprint” CVD = Cardiovascular disease JOURNAL OF THEAMERICAN DIETETICASSOCIATION Stover, P, et al. J Am Diet Assoc. 108 (9), Sep. 2008

  4. Genetic and Epigenetic Contributions to Human Nutrition and Health: Managing Genome-Diet Interactions Nutrition/Metabolism Genome Folate-mediated one-carbon metabolism is a conduit between the cellular 628 nutrient environment and genome synthesis and methylation. ATP/ADP NADP+/NADPH Folate Vitamin B6 Vitamin B12 Riboflavin Zinc Iron Amino Acids Carbohydrates DNA Synthesis - Deoxyribonucleotides Chromatin Structure - DNA Methylation -Histone Methylation One-Carbon Metabolism ATP = Adenosine Triphosphate ADP = Adenosine Diphosphate NADP+ = Nicotinamide adenine dinucleotide phosphate NADPH = Reduced form of NADP+ DNA =Deoxyribonucleic acid JOURNAL OF THEAMERICAN DIETETICASSOCIATION Stover, P, et al. J Am Diet Assoc. 108 (9), Sep. 2008

  5. Genetic and Epigenetic Contributions to Human Nutrition and Health: Managing Genome-Diet Interactions Possible genomic criteria for establishing dietary requirements. • Possible genomic criteria for setting the EAR and UL • Uracil in DNA • Mutation rate • Protein profiles • Genome methylation • Gene expression profiles EAR = Estimated Average Requirement; UL = Tolerable Upper Intake Levels RDA = Recommended Dietary Allowances DNA = Deoxyribonucleic Acid JOURNAL OF THEAMERICAN DIETETICASSOCIATION Stover, P, et al. J Am Diet Assoc. 108 (9), Sep. 2008

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