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Phyre2: PhyreAlarm. PSI-Blast vs sequence database. User sequence. Hidden Markov model of user sequence. HMM. SVYDAAAQLTADVKKD… …. Newly solved PDB Structures a dded WEEKLY. Newly added structure HMMs. hmm-hmm matching. Confident hit?. Yes. Perform full Phyre modelling. No.
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Phyre2:PhyreAlarm PSI-Blast vs sequence database User sequence Hidden Markov model of user sequence HMM SVYDAAAQLTADVKKD……. Newly solved PDB Structures added WEEKLY Newly added structure HMMs hmm-hmm matching Confident hit? Yes Perform full Phyremodelling No Email results New 3D model Try again next week