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Bottom -up curation of terminology for experimental variables: the Ontology of Experimental Variables and Values ( OoEVV ). Gully APC Burns, Jessica A Turner . Science is Cyclic. Cycles of Scientific Investigation ( ‘ CoSI ’ model). ☐ ☐ ☐☐ ☐☐ ☐☐ ☐. Focus on Experimental V ariables.
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Bottom-up curation of terminology for experimental variables: the Ontology of Experimental Variables and Values (OoEVV) Gully APC Burns, Jessica A Turner
Science is Cyclic Cycles of Scientific Investigation (‘CoSI’ model) ☐ ☐☐☐ ☐☐☐☐☐
Focus on Experimental Variables ‘CDNF protects nigral dopaminergic neurons in-vivo’ This statistically-significant effect is the experimental basis for the findings of this study. from Lindholm, P. et al. (2007), Nature, 448(7149): p. 73-7 Cycles of Scientific Investigation (‘CoSI’ model) ☐☐☐☐ ☐☐☐☐☐
Capturing Experimental Variables in Context http://www.bioscholar.org/ Knowledge Engineering from Experimental Design (KEfED) ☐☐ ☐ ☐☐☐☐☐
Knowledge Engineering from Experimental Design (‘KEfED’) Khan et al. (2007), J. Neurosci. 27:7344-60 [expt 2] Knowledge Engineering from Experimental Design (KEfED) ☐☐ ☐ ☐☐☐☐☐
OoEVV Basic Design Mathematical encoding of the variable Quality being measured (conceptual, no encoding) Variable measuring the quality 1 1 * * Scale Quality Variable ‘Handedness’ Simple-handedness-category [‘left’, ‘right’, ‘ambidextrous’] Edinburgh-handedness-score [ -100 … +100 ] Ontology of Variables and Values (OoEVV) ☐☐☐☐ ☐☐☐☐
OoEVVImplementation Ontology of Variables and Values (OoEVV) ☐☐☐☐ ☐☐☐☐
Measurement Scales Ontology of Variables and Values (OoEVV) ☐☐☐☐ ☐☐☐☐
Software Development Ontology of Variables and Values (OoEVV) ☐☐☐☐ ☐☐☐☐
OoEVVSoftware http://www.isi.edu/projects/ooevv/ooevv_software Ontology of Variables and Values (OoEVV) ☐☐☐☐ ☐☐☐☐
OoEVV Viewer Ontology of Variables and Values (OoEVV) ☐☐☐☐ ☐☐☐☐
Acknowledgements BMKEG@ISI Marcelo Tallis Drashti Dave Ed Hovy Biomedical Informatics Research Network (BIRN) Joe Ames Jose Luis Ambite Naveen Ashish Funding FBIRN: RR021992 BIRN: RR025736 CogPO: MH084812 BioScholar: GM083871 Thank you for listening!