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Governance of a Stroke Thrombolysis Service. Barry Moynihan. Framework. Pathway Protocols Outcomes Process Clinical Monitoring Local M&M SITS/NICE. and of course…………………. Training & Education. Pathway. Mapping Geography & People Where the drug is given. Protocols. Pre-hospital
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Governance of a Stroke Thrombolysis Service Barry Moynihan
Framework • Pathway • Protocols • Outcomes • Process • Clinical • Monitoring • Local M&M • SITS/NICE
Pathway • Mapping • Geography & People • Where the drug is given
Protocols • Pre-hospital • Hospital assessment & administration • Inclusion/exclusion checklist • Thrombolysis proforma • The 1st 24 hours • Nursing care plan • What to do about deterioration • Repeat brain imaging • Outcomes
Outcomes • Process • ‘door to needle time’ • Clinical • Death • Haemorrhage • NIHSS • Modified Rankin Score
Extracranial Intracranial Symptomatic Asymptomatic Haemorrhage after stroke rtPA
NIHSS • National Institutes of Health Stroke Scale • 15 point clinical scale • Predicts lesion size & outcome • Validated • Requires certification
Modified Rankin Score (mRS) 0 No symptoms at all 1 No significant disability despite symptoms; able to carry out all usual duties and activities 2 Slight disability; unable to carry out all previous activities, but able to look after own affairs without assistance 3 Moderate disability; requiring some help, but able to walk without assistance 4 Moderately severe disability; unable to walk without assistance and unable to attend to own bodily needs without assistance 5 Severe disability; bedridden, incontinent and requiring constant nursing care and attention 6 Dead
Monitoring • Local • Clinical Networks • National • SITS • NICE • SINAP
What is SITS? • 2000: SITS set up in Sweden for local purposes (Svenska Implementeringskommittén för Trombolys vid Stroke) • 2001: EMEA licensed Alteplase until 2005 on 2 conditions: • There was a trial of therapy at 3-4 hours • All patients were entered onto the SITS register.
Thrombolysis with alteplase for acute ischaemic stroke in the Safe Implementation of Thrombolysis in Stroke-Monitoring Study (SITS-MOST): an observational study. Lancet. 2007 Jan 27;369(9558):275-82
SITS (Safe Implementation of Thrombolysis in Stroke) prospective internet-based audit of the International Stroke Thrombolysis Registry (ISTR)
NICE 2007 This appraisal covers the use of Alteplase in acute ischaemic stroke.
SINAP Local Monthly Report Feb 2011 • Admissions • Total: 134 • Stroke: 77 (57%) • TIA: 22 (16%) • Non Stroke: 35 (26%) • Thrombolysis • Total Thrombolysed:7 (9% of patients with a diagnosis of stroke – one as part of IST3) • 100% eligible cases • Mean DTN time 49 mins (32 minutes Feb 2012) • DTN > 60 mins exceptions • IST3 70 mins • 90 mins (45 mins to confirm time of onset in aphasic pt)
Summary • Pathway • Protocols • Outcomes • Monitoring • Training
Useful Links • http://nihss-english.trainingcampus.net/uas/modules/trees/windex.aspx • http://www.rankinscale.org/links.shtml • http://www.acutestroke.org/ • http://www.nice.org.uk/guidance/TA122 • http://www.rcplondon.ac.uk/clinical-standards/ceeu/Current-work/stroke/Pages/SINAP.aspx