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Lecture 12 LIPID METABOLISM FATTY ACID OXIDATION

Lecture 12 LIPID METABOLISM FATTY ACID OXIDATION. September1, 2006 Lehninger (4 th Edition), Chapter 17. FATTY ACID DEGRADATION (OXIDATION) LNC Chapter 17. LNC 10-1. LNC 10-6. LNC 10-8. LNC 10-15. LNC 10-16. UPTAKE and DISTRIBUTION in Mammals. LNC 17-1. ADIPOSE TISSUE. LNC 21-40.

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Lecture 12 LIPID METABOLISM FATTY ACID OXIDATION

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  1. Lecture 12LIPID METABOLISMFATTY ACID OXIDATION • September1, 2006 • Lehninger (4th Edition), Chapter 17

  2. FATTY ACID DEGRADATION (OXIDATION) LNC Chapter 17

  3. LNC 10-1

  4. LNC 10-6

  5. LNC 10-8

  6. LNC 10-15

  7. LNC 10-16

  8. UPTAKE and DISTRIBUTION in Mammals

  9. LNC 17-1

  10. ADIPOSE TISSUE LNC 21-40

  11. Chylomicron LNC 17-2

  12. Structure of an LDL particle LNC 21-39a

  13. LNC 21-39b

  14. Breakdown/Oxidation of Fatty Acids b-Oxidation

  15. Activation LNC 17-5

  16. LNC 17-6

  17. C14fatty acid 7 acetyl CoA 6 rounds of b oxidation

  18. LNC 17-7

  19. LNC 19-8

  20. How to deal with unsaturated fatty acids: cis D3 - or double bond between b-g LNC 17-9

  21. LNC 17-10

  22. How to deal with a fatty acid containing an uneven number of carbons C3 C4 LNC 17-11

  23. LNC box 17-1

  24. LNC box 17-2

  25. Degradation of very long chain fatty acids in the peroxisome catalase LNC 17-12

  26. succinate Glyoxalate Cycle in Plants LNC 17-13

  27. Ketone Bodies

  28. Conditions favoring ketone body formation: depletion of OA for gluconeogenesis acetyl-CoA becomes available for ketone body synthesis LNC Fig 17-18

  29. Skip the details on the metabolism of ketone bodies

  30. Metabolic Biochemistry FATTY ACID SYNTHESIS LNC Chapter 21

  31. acetyl-CoA + CO2 ==> malonyl-CoA the enzyme has three functional regions: - biotin carrier protein - biotin carboxylase - transcarboxylase LNC Fig. 21-1

  32. LNC Fig. 21-4

  33. acyl carrier protein LNC Fig. 21-2

  34. LNC Fig. 21-2

  35. LNC Fig. 21-2

  36. This group is transferred to the other SH group to free the ACP-SH for the next malonyl group LNC Fig. 21-2

  37. LNC Fig. 21-3

  38. LNC Fig. 21-5

  39. LNC Fig. 21-5

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