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ICY THERAPY spot treats CANCER in the lung

ICY THERAPY spot treats CANCER in the lung. E valuating C ryoablation of Metastatic L ung/Pleura Tumors I n P atients – S afety and E fficacy. ECLIPSE. de Baere T 1 ; Woodrum D 2 ; Abtin F 3 ; Littrup P 4 ; Farouil G 1.

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ICY THERAPY spot treats CANCER in the lung

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  1. ICY THERAPYspot treats CANCER in the lung

  2. EvaluatingCryoablation of MetastaticLung/Pleura Tumors InPatients – SafetyandEfficacy ECLIPSE de Baere T1 ; Woodrum D2 ; Abtin F3 ; Littrup P4 ; Farouil G1 1. Institut de Cancerologie Gustave Roussy, VILLEJUIF Cedex, France 2. Mayo Clinic, Rochester, MN, United States 3. Unv. of California-Los Angeles, Los Angeles, CA, United States 4. Karmanos Cancer Institute, Detroit, MI, United States

  3. Multicenter, prospective, single arm study Dr. Thierry de Beare Institut de Cancerologie Gustave Roussy, VILLEJUIF Cedex, France 2. Dr. David Woodrum Mayo Clinic, Rochester, MN, United States 3. Dr. F Abtin Unv. of California-Los Angeles, Los Angeles, CA, United States 4. Dr. Peter Littrup Karmanos Cancer Institute, Detroit,MI, United States

  4. Objective Assess the role of CT guided cryoablation in targeted treatment of small to medium metastatic tumors in the lung

  5. Why Ablation versus Surgery • Many of the patients are not surgical candidates • Cryoablation usually requires only an overnight stay in the hospital • Shorter recovery time

  6. Inclusion Criteria • Pulmonary metastatic disease • Up to 5 pulmonary metastases (≤3.5 cm) with no more than 3 on one side.

  7. Exclusion Criteria • Primary NSLC lung cancer • Inability to lie flat or respiratory distress at rest • Uncontrolled coagulopathy or bleeding disorders

  8. Demographics BMI Age Max: 44 Max: 83 Avg: 27 Min: 15 Min: 26 Avg: 63

  9. Primary Cancer Diagnosis

  10. Procedure Data Tumor Size (cm) Tumor Locations Bilateral 20% Min: 0.3 Avg: 1.4 Max: 3.2 Unilateral 80% Confidential 10

  11. Procedure Data Confidential 11

  12. Side Effects CTCAE Grade Top Five Grade 3 Events • Non-Cardiac Chest Pain • Pneumothorax requiring VATS • AV Fistula thrombosis requiring thrombectomy Adverse Event Number Rate Per Procedure Pneumothorax Pleural Effusion Pain: Chest/Back Hemorrhage Cough 24 10 6 4 3 50% 21% 13% 8% 6% Confidential 12

  13. Response Rate 100% 95% 100%

  14. Lung Cryoablation Axial Probe Placement Lung Metastasis Needles In Tumor Lung Tumor Coronal Probe Placement Freezing Ice Ball Edge

  15. Take Home Points • Cryoablationof lung tumors mets ≤3.5 cm appears safe and efficacious • Preliminary short-term results offer promising local tumor control • Larger experience and longer follow-up is necessary

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