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The Research Paradigm: Scientific Agenda Valerie Odero-Marah , PhD

The Research Paradigm: Scientific Agenda Valerie Odero-Marah , PhD. Dr Shafiq Khan Lab Transforming Growth Factor beta (TGF- b ) signaling How TGF- b promotes tumor progression The role of the different TGF- b isoforms. Dr Jaideep Chaudhary Lab Inhibitors of Differentiation (Id)

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The Research Paradigm: Scientific Agenda Valerie Odero-Marah , PhD

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  1. The Research Paradigm: Scientific Agenda Valerie Odero-Marah, PhD

  2. Dr Shafiq Khan Lab • Transforming Growth Factor beta (TGF-b) signaling • How TGF-b promotes tumor progression • The role of the different TGF-b isoforms

  3. Dr Jaideep Chaudhary Lab • Inhibitors of Differentiation (Id) • Promotes tumor progression • Viruses causing prostate cancer • Pathway of action

  4. Dr Valerie Odero-Marah Lab • Snail transcription factor • Promotes tumor progression via reactive oxygen species • Promotes metastasis to bone

  5. Dr. Cimona V. Hinton Lab • PTEN and CXCR4 • Studying how loss of tumor suppressors permits metastasis enhancing genes. PTEN usually lost early in cancer progression CXCR4 associated with metastasis

  6. Dr Godwin Ananaba Lab • Role of Sterols in prostate cancer • How high cholesterol and low phytosterol can promote prostate cancer • Using cyclodextran compounds as a delivery system

  7. Sources of Funding • National Institute of Health (NIH): RCMI, P20 • National Cancer Institute (NCI): RO1 • Department of Defense (DOD): Idea, New Investigator, Pca Training Grant • Georgia Research Alliance (GRA): equipment and personnel

  8. Publications and Presentations • May 2009-April 2010: 11 journal articles • 50 presentations in national meetings

  9. Research Facilities • Molecular Biology • Cell Biology • Structural Biology • Histology • Bioinformatics and Biostatistics • Analytical

  10. Collaborative Center for Cancer Genomics (CCGC) • Collaborative effort between Clark Atlanta University and Ovarian Cancer Institute at Georgia Tech • Gene expression analysis of individual patients

  11. Prostate Cancer Tissue Bank • Collaboration between Saint Joseph’s hospital and Georgia Tech • Intend to acquire prostate cancer patient samples for analysis at the Genomics center • Intend to establish a prostate cancer tissue bank

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