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Sotheavy Vann Ngoc Phan

Evidence that talin alternative splice variants from Ciona intestinalis have different roles in cell adhesion. Sotheavy Vann Ngoc Phan. What are Talins?. Modular cytoskeletal proteins-cell adhesions Talin 1 and 2 have non-redundant roles Talin 1-focal cell adhesion and cellular motility

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Sotheavy Vann Ngoc Phan

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  1. Evidence that talin alternative splice variants from Ciona intestinalis have different roles in cell adhesion Sotheavy Vann Ngoc Phan

  2. What are Talins? • Modular cytoskeletal proteins-cell adhesions • Talin 1 and 2 have non-redundant roles • Talin 1-focal cell adhesion and cellular motility • Talin 2-lables F-actin stress fibers for stable adhesion assemblies • C. Intestinalis-talin a and talin b • Why study talins?

  3. Ciona Intestinalis http://www.google.com/url?source=imglanding&ct=img&q=http://cfb.unh.edu/phycokey/Choices/Anomalous_Items/Chordates/tunicates/tunicate_03_600x450_larvae_riley_nolan.jpg&sa=X&ei=XLiFT9ePDYie8gT15cXCCA&ved=0CA0Q8wc4FQ&usg=AFQjCNGQ0Y-9A4X0sBmrUGdJaCGDTbektg Phylum Chordata Life Cycle Good Model Organism http://upload.wikimedia.org/wikipedia/commons/thumb/f/fe/Cionaintestinalis.jpg/220px-Cionaintestinalis.jpg

  4. Expressed Sequence Tag • Gene Discovery Tool • EST Method • Involves the Central Dogma of genetics • Other Methods • Searching for signal sequences • Comparing genomes

  5. Distribution of Talin-a and Talin-b

  6. Phylogeny

  7. Alternative Splicing

  8. Alternative Splicing

  9. Immunoflourescence

  10. Actin binding of Talin-a and Talin-b I/LWEQ modules

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