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Molecule of the week: Viagra

Molecule of the week: Viagra. Viagra (sildenafil citrate) is used for the treatment of erectile disfunction in men. How it works: Arousal causes the release of NO from nerves in genitalia NO stimulates production of cyclic GMP

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Molecule of the week: Viagra

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  1. Molecule of the week: Viagra Viagra (sildenafil citrate) is used for the treatment of erectile disfunction in men. • How it works: • Arousal causes the release of NO from nerves in genitalia • NO stimulates production of cyclic GMP • Cyclic GMP causes vasodilation; changes in blood flow and smooth muscles of vessels. • Sildenafil citrate inhibits • breakdown of cyclic GMP by phosphodiesterases so • vessels stay dilated. Manufactured by Pfizer, FDA approved in Mar 1998 Side effects: fainting, dizziness, headaches, blurred or blue vision (cyc GMP in retina!)

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