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Patricia Batista

Patricia Batista. Capsaicin. active component of chili peppers; burning and painful sensations; actives a distinct subpopulation of primary sensory neurons;

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Patricia Batista

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  1. Patricia Batista

  2. Capsaicin • active component of chili peppers; • burning and painful sensations; • actives a distinct subpopulation of primary sensory neurons; • TRPV1 also respond to noxious heat (> 43ºC), extracellular protons (pH <6) (Tominaga et al., 1998), and its endogenous ligands as anandamide (Di Marzo et al., 2001), N-arachidonoyl-dopamine (Hwang et al., 2002) and products of lipoxygenases (Hwang et al., 2000).

  3. Steroid Hormones • Effects are mediated by genomic steroid response elements; • Modulate directly excitatory glutamate and GABAA and glycine receptors; • Neurosteroids (DHA and pregnenolone sulfate) inhibit the TRPV1-mediated current in DRG neurons (Chen et al., 2004; Chen and Wu, 2004).

  4. Steroid Hormones

  5. ?????? • There is a sex difference in the capsaicin-induced nocifensive response? • Mechanisms underlying this sex difference?

  6. Sex difference in capsaicin-induced nocifensive response

  7. Estrus cycle difference in capsaicin-induced nocifensive response 6 weeks after OVX Cap ED50 1.5 fold estrus > proestrus Estrus: [E2]plasma Proestrus: [E2]plasma

  8. E2 potentiates the capsaicin-induced nocifensive response in males Bis I -> PKC inhibitor H89 -> PKA inhibitor

  9. L-NAME effect in the cold-induced nocifensive response Cold plate <2ºC

  10. Estrous cycle effect on acetone test in CCI mice 7 days after surgery

  11. Estrous cycle effect on acetone test in CCI mice 14 days after surgery

  12. THANK YOU!!!

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