1 / 91

The chemical Basis of Inheritance

The chemical Basis of Inheritance. Chromatin / Chromosomes. Organism estimated size estimated gene number average gene density chromosome # Homo sapiens (human) 2900 million bases ~30,000 1 gene per 100,000 bases 46

kasen
Download Presentation

The chemical Basis of Inheritance

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. The chemical Basis of Inheritance

  2. Chromatin / Chromosomes

  3. Organism estimated size estimated gene number average gene density chromosome # Homo sapiens (human) 2900 million bases ~30,000 1 gene per 100,000 bases 46 Rattus norvegicus (rat) 2,750 million bases ~30,000 1 gene per 100,000 bases 42 Mus musculus (mouse) 2500 million bases ~30,000 1 gene per 100,000 bases 40 Drosophila melanogaster 180 million bases 13,600 1 gene per 9,000 bases 8 (fruit fly) Arabidopsis thaliana 125 million bases 25,500 1 gene per 4000 bases 5 (plant) Zea mays (corn) 5000 million bases ~25,000 1 gene per 200,000 bases 10 Oryza sativa (rice) 565 ~25,000 1 gene per 23000 bases 12 Caenorhabditis elegans 97 million bases 19,100 1 gene per 5000 bases 6 (roundworm) Saccharomyces cerevisiae 12 million bases 6300 1 gene per 2000 bases 16 (yeast) Escherichia coli 4.7 million bases 3200 1 gene per 1400 bases 1 (bacteria) H. influenzae (bacteria) 1.8 million bases 1700 1 gene per 1000 bases 1

  4. Chromosome = Protein + DNA

  5. Indirect Evidence of DNA as genetic material

  6. Bacteria transforming factor- Griffiths 1928

  7. Hershey and Chase Expt. 1952Viral Life Cycle I

  8. Viral Life cycle II attachment, penetration, replication, assembly, lysis

  9. Hershey and Chase – Protein coat labeled virus

  10. Hershey and Chase – DNA labeled virus

  11. 32P - Radioactivity appear in progeny

  12. 35S – No Radioactivity in progeny

  13. Hershey and Chase

  14. Watson and Click Model 1953

  15. DNA –A Double Helix

  16. DNA – Sugar phosphate backbone

  17. DNA – Polynucleotide chain

  18. DNA – A Nucleotide unit

  19. DNA – Sugar / pentose

  20. Pyrimidine DNA – Organic Bases Purines

  21. DNA – Base pairing

  22. DNA – Base pairing

  23. DNA – 2 antiparallel chains

  24. DNA vs RNA

  25. DNA vs RNA

  26. DNA - The molecule of life • Each cell: • 46 chromosomes • 2 meters of DNA • 3 billion DNA bases • Approximately 30,000 genes

  27. From DNA to Human

  28. DNA replication – overall process

  29. DNA replication

  30. Three models of DNA replication

  31. Evidence for a Semi-conservative model

  32. Semi-conservative replication

  33. DNA replication

  34. The triplet code I

  35. The triplet code II- start

  36. The triplet code III- termination

  37. The triplet code IV- degenerate

  38. The triplet code IV- Non-overlapping

  39. The triplet code V –no punctuation

  40. Breaking the code

  41. Breaking the code

  42. Central Dogma

  43. Transcription

  44. Transcription- animated

  45. Transcription- coding strand

  46. Replication - transcription -translation

  47. t-RNA

  48. t-RNA binding sites

  49. Aminoacyl-tRNA complex

  50. Ribosome – Pro- and Eukaryotic

More Related