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Zeleke Mekonnen 1 , Bruno Levecke 2 , Ahmed Zeynudin 1 , Jozef Vercruysse 2

Conclusion. Objectives. Materials and Methods. Introduction. Reference. Results and Discussion. Monitoring drug efficacy of albendazole against soil-transmitted helminth infections in school age children, Jimma (Ethiopia).

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Zeleke Mekonnen 1 , Bruno Levecke 2 , Ahmed Zeynudin 1 , Jozef Vercruysse 2

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  1. Conclusion Objectives Materials and Methods Introduction Reference Results and Discussion Monitoring drug efficacy of albendazole against soil-transmitted helminth infections in school age children, Jimma (Ethiopia). Zeleke Mekonnen1, Bruno Levecke2, Ahmed Zeynudin1, Jozef Vercruysse2 1Department of Medical Laboratory sciences and Pathology, College of Public health and Medical Sciences, Jimma University, Ethiopia. 2Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Belgium The three major soil-transmitted helminths (STH) Ascaris lumbricoides, Trichuris trichiura and Necator americanus/Ancylostoma duodenale are among the most widespread parasites worldwide. Despite the global expansion of preventive anthelminthic treatment, programs to monitor anthelminthic drug efficacy are lacking. A total of 410 children participated in this trial. More than 60% of the subjects were infected with at least one of the three STH (Figure 1). A. lumbricoides was the most prevalent(Table 1). Almost all of the treated subjects provided a second sample at follow-up. Albendazole was highly efficacious against A. Lumbricoides and hookworms (> 99%), but less for T. trichiura (Table 1). To define the efficacy of a single 400 milligram dose of albendazole (ALB) against these three STH using a standardised protocol in school age children of Jimma (Ethiopia). Table 1. The number of infected subjects and the efficacy of albendazole treatment against STH • A. Study subjects: • School age children (4-18 years) • Jiren number 1 elementary school • Jimma (Ethiopia) • May-June,2009 • B. Trial design: • Coprological examination: • McMaster technique • Enumeration of faecal egg counts (FEC) • Treatment of infected subjects: • Single dose of albendazole (400mg) • Coprological examination: • 14 days post treatment • McMaster technique • Enumeration of faecal egg counts (FEC) Figure 1. The distribution of STH infections in school age children, Jimma Ethiopia. This study indicates that STH infections are highly prevalent in school age children in Jimma (Ethiopia) and warrants further actions. A single albendazole treatment was highly efficacious, but less for T. trichiura. For this parasite, a repeated single dose on consecutive days likely to be more appropriate, nevertheless, it needs further investigation. • C. Statistical analysis • Reduction in FEC • mean (FEC post treatment) • mean (FEC pre-treatment) 100%x (1- ) Geerts and Gryseels, 2001, Albonicoet al., 2004 Vercruysse et al.,2010 This is PhD work done in the context of the IUC-JU project Contacts: PhD student: zeleke.mekonnen@ju.edu.et; supervisor: jozef.vercruysse@Ugent.be

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