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2009 년 4 분기 미토콘드리아 유전체 연구팀 ( mtDNA research lab)

2009 년 4 분기 미토콘드리아 유전체 연구팀 ( mtDNA research lab). 2009.12.30 원양회관. 정리 내용. 연구원 동정 학술대회 참가 및 연제발표 투고 SCI 논문 연구과제 수행. 연구원 동정. 현재 신명근 교수님 , 김혜란 , 오지연 , 김환영 , 엄하영 , 안애자 연구원 2009. 1. 19 오지연 연구원 시작 2009. 02. 27 김혜란 박사학위 및 김명숙 , 조정애 석사학위수여

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2009 년 4 분기 미토콘드리아 유전체 연구팀 ( mtDNA research lab)

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  1. 2009년 4분기 미토콘드리아 유전체 연구팀 (mtDNA research lab) 2009.12.30 원양회관

  2. 정리 내용 • 연구원 동정 • 학술대회 참가 및 연제발표 • 투고 SCI논문 • 연구과제 수행

  3. 연구원 동정 • 현재 신명근 교수님,김혜란, 오지연, 김환영, 엄하영, 안애자 연구원 • 2009. 1. 19 오지연 연구원 시작 • 2009. 02. 27 김혜란 박사학위 및 김명숙, 조정애 석사학위수여 • 2009. 03. 02 엄하영 샘석사학위 및 mtDNA연구실연구원 시작 • 2009. 04. 03 2009 mtDNA연구실 1분기 모임 • 2009. 05. 28 김환영 연구원 시작 • 2009. 06. 01 안애자 샘 석사학위 및 mtDNA연구실연구원 시작 • 2009. 6. 25 2009 mtDNA연구실 2분기 모임 • 2009. 9.30 2009 mtDNA연구실 3분기 모임 • 2009. 10.22 신명근 교수님 진단검사의학회 포스터 상 수상 • 2009. 12.3-8 신명근 교수님, 김혜란박사 미국 ASH 학회 참가 • 2009. 12. 30 2009 mtDNA연구실 4분기 모임

  4. 학술대회 참가 및 연제발표 • 세브란스병원 유전자은행 개소 심포지엄 “Alteration of mitochondrial genome and Proteome in chronic inflammatory diseases and hematological malignancies: implication for the development of new molecular biomarkers and targeted therapeutics” (신명근)/2009.11.26 (연세대학교 의과대학 종합관 331호) 연자발표 • 심장질환 치료기술 개발 특성화 연구센터 “Development of new molecular biomarkers in chronic inflammatory disease and cancers using mitochondria genome and proteome analysis” (신명근)/2009.11.24 (전남대학교 의과대학) 연자발표 • The 18th KOGO Conference Omics to Personal Medicine “Oxidative Stress, Mitochondrial Dysfunction and Mitochondrial Genome Aberration in Chronic Inflammatory Tissue and Hematopoietic Diseases”(신명근)/2009. 9.10 (Samsung Medical Center, Seoul, Korea) 연자발표

  5. 09 추계 진단검사의학회/2009. 10.22(대구 인터불고 호텔) • 1) “Different proportion of leukemia stem cells according to AML FAB subtypes and their lower single cell dividing property” (신명근, 김혜란) 포스터발표 • 2) “Association of the prohibitin 3’untranslated region polymorphisms with increased risk of AML”(신명근, 김혜란) 포스터발표 • 3) “Remarkable discrepancy between allele-specific PCR and real-time PCR melting curve analysis in detection rate of JAK2 V617F mutation”(신명근, 김혜란) 구연발표

  6. 09 51th ASH학회 (미귝, 뉴올리언즈) • “AML FAB subtypes shows different proportion of leukemia initiating cell which has lower single cell dividing property”(김혜란, 신명근) • “Increased mitochondrial mass and mitochondrial DNA copy numbers are biomarkers for benzene exposure in hematopoietic tissue and leukemia cells”(신명근, 엄하영, 김혜란) • 3) “Profound length heteroplasmic alterations in mitochondrial DNA • control region from primary AML cells: implication of impaired • mitochondrial replication and demonstration of ‘vicious cycle’ • hypothesis” (신명근, 김혜란)/포스터발표 • 4) “The Prohibitin 3’ untranslated region polymorphisms are associated • with AML susceptibility” (김혜란, 신명근)

  7. 1st Korean Myeloma Workshop “MRD markers of multiple myeloma”(신명근)/ 2009. 6. 20 (화순전남대병원 대강당) 연자발표 • 3rd International WHO Conference on Children’s Health and the Environment “ Short-term effect and profiling of mitochonrial genomic instability in leukemia cell lines ex vivo after benzene exposure”(엄하영, 신명근, 김혜란)/ 2009.6.7-10(BusanBexco)포스터발표 • 2009년 제50차 대한혈액학회 춘계학술대회 • 1)“Benzene Exposure was Associated with Increased Mitochondrial Mass in Leukemia Cell Lines” (엄하영, 신명근, 김혜란, 오지연)/ 2009. 5. 29 (서울 홍은동 그랜드힐튼호텔) 포스터발표 • 2) “Clonality Assay in the Lymphoid Neoplasm”(신명근)/ 2009. 5. 30(서울 홍은동 그랜드힐튼호텔)연자발표

  8. 3)“Demonstration of Multiple Myeloma Cell-specific mtDNA Mutations in Bone Marrow Cells at an Initial Diagnosis” (신명근, 김혜란)/ 2009. 5. 29 (서울 홍은동 그랜드힐튼호텔) 구연발표 4)“The First Korean Case of Aplastic Anemia in Cohen Syndrome Documented by Mutation Analysis” (김혜란, 신명근)/ 2009. 5. 29 (서울 홍은동 그랜드힐튼호텔) 포스터발표 5)“Spectrum of Length Heteroplasmic Aberrations in Mitochondrial DNA from Primary AML Cells: Implication of Impaired Mitochondrial Replication and ATP Synthesis” (신명근, 김혜란)/ 2009. 5. 29 (서울 홍은동 그랜드힐튼호텔) 포스터발표

  9. SET-NUP214 Fusion Gene Contributed to the Development of AML with Minimal Differntiation and T-ALL”(신명근, 김혜란)/ 2009. 5. 29(서울 홍은동 그랜드힐튼호텔) 포스터 발표 • “Distribution and Proportion of AML Stem Cells to FAB Classification and CD34+ Fraction in Bone Marrow Specimens and Lower Dividing Property of AML Stem Cells in Single Cell Suspension Culture System”(김혜란, 신명근) / 2009.5. 29(서울 홍은동 그랜드힐튼호텔)구연발표 • 대한진단검사의학회2009년 춘계 심포지엄 Laboratory Medicine: Back to the Basics “MyeloproliferativeNeoplasms, MPN”(신명근) / 2009. 4.9(W Seoul-Walkerhill Hotel ) 연자발표

  10. 2009 4분기투고 SCI논문 ★ 주저자 및 교신저자 1) Choi HJet al. Detection of putative T cell clones using T cell receptor β chain gene clonality assay in Korean patients with aplastic anemia. Korean J Lab Med.SCIE-indexed 2009 Aug;29(4):269-76. 2) Kim HRet al. Alteration of mitochondrial DNA sequence and copy number in nasal polyp tissue. Mitochondrion.SCI-indexed 2009 Sep;9(5):318-25. 3) Kim DW et al. Incidence and Causes of Eosinophilia from the Patients in a University Hospital. Korean J Lab Med. SCIE-indexed 2009 Jun;29(3):185-93 4) Shin MG et al. Application and usefulness of multiplex reverse transcription-polymerase chain reaction for simultaneous screening of 28 translocations and chromosomal aberrations in leukemia. Korean J Lab Med, SCIE-indexed 2009, under revision

  11. ★ 공저자 Kim DW, Shin JH, Kee SJ, Kim SH, Shin MG, Suh SP, Ryang DW.“Evaluation of VITEK-2 Antifungal Susceptibility Test (AST-YS01) for Candida Species Isolates in Korea. ” Korean J Lab Med.2009 Sep;12(3):122-128. Kim SH, Cho D, Kee SJ, Shin MG, Shin JH, Suh SP, Ryang DW.“Allele-related Variation in Minisatellite Repeats Involved in Transcription of the ABO Gene in Korean Blood Donors.” Korean J Lab Med.2009 Sep;44(3):127-132. 3) Moon CJ, Shin JH, Jeong ES, Kee SJ, Kim SH, Shin MG, Suh SP, Ryang DW.“Central Venous Catheter-Related MicrobacteriumBacteremia Identified by 16S ribosomal RNA Gene Sequencing .”  Korean J Lab Med. 2009 Jun;12(2):97-101. 4) Yun HK, Kim SH, Cho D, Kee SJ, Shin MG, Shin JH, Suh SP, Ryang DW.“Comparison of Two Sputum Processing Methods for Detecting Mycobacterium tuberculosis by Culture and PCR: Universal Sample Processing(USP) and NALC-NaOH Methods.” Korean J Lab Med.2009 Jun;12(2):67-71.

  12. 5) Kee SJ, Kim SM, Kim SH, Shin MG, Shin JH, Suh SP, Ryang DW. “Multiplex PCR Assay for Identification of Mycobacterial Species Isolated from Liquid Cultures.” Kor J Lab Med (SCIE) 2009, 45(1):19-26. 6) Moon CJ, Shin JH, Kim DW, Kee SJ, Kim SH, Shin MG, Suh SP, Ryang DW. “Species-Specific Differences in Rhodamine 6G Accumulation of Candida Isolates Detected by Flow Cytometric Analysis.” Korean J Lab Med.2009 Apr;29(2):127-134. 7) Cho SH, Huh JW, Kim YJ, Shin MG, Kim HR. “APC Mutation Spectra in Sporadic Colon Cancer Tissue among Korean.” Kor J Lab Med (SCIE) 2009, 76(3):159-167. 8)Kim MN, Shin JH, Sung H, Lee K, Kim EC, Ryoo N, Lee JS, Jung SI, Park KH, Kee SJ, Kim SH, Shin MG, Suh SP, Ryang DW. “Candida haemulonii and closely related species at 5 university hospitals in Korea: identification, antifungal susceptibility, and clinical features.” Clin Infect Dis. 2009, 15;48(6):e57-61.

  13. 9) Kim SH, Shin JH, Kim EC, Lee K, Kim MN, Lee WG, Uh Y, Lee HS, Lee MK, Jeong SH, Jung SI, Park KH, Lee JS, Shin MG, Suh SP, Ryang DW. “The relationship between antifungal usage and antifungal susceptibility in clinical isolates of Candida: a multicenter Korean study.” Med Mycol. 2009, 47(3):296-304. Epub 2008 Jul 30. 10) Song JW, Shin JH, Kee SJ, Kim SH, Shin MG, Suh SP, Ryang DW. “Expression of CgCDR1, CgCDR2, and CgERG11 in Candida glabratabiofilms formed by bloodstream isolates.” Med Mycol. 2009;47(5):545-8.

  14. ★ Manuscript preparation • Association of allelic expression imbalance of JAK2 V617F mutant and phenotypic diversity in BCR-ABL negative myeloproliferative neoplasma • Direct confirmation of silent property of AML stem cells using single cell culture system • Aberrant expression of prohibitin in primary AML cells and their implication of treatment monitoring, prognosis and therapeutic approach • Spectrum of mitochondrial genome instability of primary AML cells and their clinical and pathophysiologic implication • Colon and stomach cancer-specific mitochondrial DNA mutations • The change of Mitochondrial copy number is possible biomarker of benzene exposure in leukemia cell lines

  15. 연구과제 수행 1) 단독연구과제 i) 09 과학재단 특정기초 ii) 09 보건의료기술사업 과제 2) 세부연구과제 i) 환경성 질환연구센터 세부과제

  16. 2009미국혈액학회 과장님 독사진입니다. 미토콘드리아 유전체팀 미녀들입니다. 모두의 앞날에 무궁한 발전이 있도록 우리 모두 화이팅!!! 감사합니다~

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