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Introduction to DIY Fractional Polynomials: Examples and Applications

Learn about DIY fractional polynomials, how to implement them, and their applications in clinical trials. Examples and overview provided by Patrick Royston from MRC Clinical Trials Unit in London on September 10, 2010.

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Introduction to DIY Fractional Polynomials: Examples and Applications

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  1. DIY fractional polynomials Patrick Royston MRC Clinical Trials Unit , London 10 September 2010

  2. Introduction to fractional polynomials Going off-piste: DIY fractional polynomials Examples Overview

  3. Afractional polynomial of degree 1 with power p1 is defined as FP1 = β1 X p1 Afractional polynomial of degree 2 with powers (p1,p2) is defined as FP2 = β1 X p1 + β2 X p2 Powers (p1,p2) are taken from a predefined set S = {2,  1,  0.5, 0, 0.5, 1, 2, 3} where 0 meanslog X Also, there are ‘repeated’ powers FP2 models Example: FP1 [power 0.5] = β1 X0.5 Example: FP2 [powers (0.5, 3)] = β1 X0.5 + β2 X3 Example: FP2 [powers (3, 3)] = β1 X3 + β2 X3lnX Fractional polynomial models

  4. Some examples of fractional polynomial (FP2) curves Royston P, Altman DG (1994) Applied Statistics 43: 429-467.

  5. FP analysis for the prognostic effect of age in breast cancer

  6. Simple functions are preferred. More complicated functions are accepted only if the fit is much betterEffect of age significant at 5% level? FP function selection procedure χ2 df P-value Any effect? Best FP2 versus null 17.61 4 0.0015 Linear function suitable? Best FP2 versus linear 17.03 3 0.0007 FP1 sufficient? Best FP2 vs. best FP1 11.20 2 0.0037

  7. fracpoly command Basic syntax: . fracpoly [, fp_options]: regn_cmd [yvar] xvar1 [xvars] … xvar1 is a continuous predictor which may have a curved relationship with yvar xvars are other predictors, all modelled as linear Can use the fp_option compare to compare the fit of different FP models uses the FP function selection procedure Fractional polynomials in Stata

  8. fracpoly, compare: regress mpg displacement Fractional polynomial model comparisons: -------------------------------------------------------------------------- displacement df Deviance Res. SD Dev. dif. P (*) Powers -------------------------------------------------------------------------- Not in model 0 468.789 5.7855 70.818 0.000 Linear 1 417.801 4.12779 19.830 0.000 1 m = 1 2 400.592 3.67467 2.621 0.284 -2 m = 2 4 397.971 3.6355 -- -- -2 3 -------------------------------------------------------------------------- (*) P-value from deviance difference comparing reported model with m = 2 model Show FP1 and FP2 models in Stata (+ fracplot) Example (auto data)

  9. fracpoly supports only some of Stata’s rich set of regression-type commands Provided we know what the command we want to fit looks like with a transformed covariate, we can fit an FP model to the data We just create the necessary transformed covariate values, fit the model using them, and assess the fit A new, simple command fracpoly_powers helps by generating strings (local macros) with the required powers: . fracpoly_powers [, degree(#) s(list_of_powers) ] But what if fracpoly can’t fit my model … ?

  10. // Store FP2 powers in local macros fracpoly_powers, degree(2) local np = r(np) forvalues j = 1 / `np' { local p`j' `r(p`j')' } // Compute deviance for each model with covariate displacement local x displacement local y mpg local devmin 1e30 quietly forvalues j = 1 / `np' { fracgen `x' `p`j'', replace regress `y' `r(names)' local dev = -2 * e(ll) if `dev' < `devmin' { local pbest `p`j'' local devmin `dev' } } di "Best model has powers `pbest', deviance = " `devmin' Fitting an FP2 model in the auto example

  11. Prospective longitudinal study of n = 50 pregnant women There are about 6 repeated measurements on each fetus at different gestational ages (gawks) gawks = gestational age in weeks Wish to model how y = log fetal abdominal circumference changes with gestational age There is considerable curvature! A real example: modelling fetal growth

  12. The raw data

  13. Multilevel (mixed) model to fit this relationship: . xtmixed y FP(gawks) || id: FP(gawks), covariance(unstructured) But how do we implement “FP(gawks)” here? We want the best-fitting FP function of gawks, with random effects for the parameters (β’s) of the FP model A mixed model for fetal growth

  14. [First run fracpoly_powers to create local macros with powers] // Compute deviance for each FP model with covariate gawks gen x = gawks gen y = ln(ac) local devmin 1e30 forvalues j = 1 / `np' { qui fracgen x `p`j'', replace adjust(mean) qui xtmixed y `r(names)' || id: `r(names)', /// nostderr covariance(unstructured) local dev = -2 * e(ll) if `dev' < `devmin' { local p `p`j'' local devmin `dev' } di "powers = `p`j''" _col(20) " deviance = " %9.3f `dev' } di _n "Best model has powers `p', deviance = " `devmin' Fitting an FP2 mixed model to the fetal AC data

  15. Plots of some results

  16. I know almost nothing about “seemingly unrelated regression” (Stata’s sureg command) It fits a set of linear regression models which have correlated error terms The syntax therefore has a set of “equations” . sureg (depvar1 varlist1) (depvar2 varlist2) ... (depvarN varlistN) There may be non-linearities lurking in these “equations” How can we fit FP models to varlist1, varlist2, … ? An “ignorant” example!

  17. Stata FAQ from UCLA (http://www.ats.ucla.edu/stat/stata/faq/sureg.htm): What is seemingly unrelated regression and how can I perform it in Stata? Example: High School and Beyond study Example: modelling learning scores

  18. Contains data from hsb2.dta obs: 200 highschool and beyond (200 cases) vars: 11 5 Jul 2010 13:23 size: 9,600 (99.9% of memory free) ------------------------------------------------------------------------------- storage display value variable name type format label variable label ------------------------------------------------------------------------------- id float %9.0g female float %9.0g fl race float %12.0g rl ses float %9.0g sl schtyp float %9.0g scl type of school prog float %9.0g sel type of program read float %9.0g reading score write float %9.0g writing score math float %9.0g math score science float %9.0g science score socst float %9.0g social studies score ------------------------------------------------------------------------------- [It is unclear to me what “ses” (low, middle, high) is] Example: modelling learning scores

  19. As an example, suppose we wish to model 2 outcomes (read, math) as predicted by “socstfemale ses” and “sciencefemaleses” using sureg as follows: . sureg (read socst female ses) (math science female ses) Are there non-linearities in read as a function of socst?In math as a function of science? For simplicity here, will restrict ourselves to FP1 functions of socst and science not necessary in principle We fit the 8 × 8 = 64 FP1 models and look for the best-fitting combination Example (ctd.)

  20. gen x1 = socst gen x2 = science gen y1 = read gen y2 = math local devmin 1e30 forvalues j = 1 / `np' { qui fracgen x1 `p`j'', replace adjust(mean) local x1vars `r(names)' forvalues k = 1 / `np' { qui fracgen x2 `p`k'', replace adjust(mean) local x2vars `r(names)' qui sureg (y1 `x1vars' female ses) (y2 `x2vars' female ses) local dev = -2 * e(ll) if `dev' < `devmin' { local px1 `p`j'' local px2 `p`k'' local devmin `dev' } } } [Run fpexample3.do in Stata] Stata

  21. The results suggest that there is indeed curvature in both relationships Can reject the null hypothesis of linearity at the 1% significance level FP1 vs linear: χ2 = 10.08 (2 d.f.), P = 0.0065 Shows the importance of considering non-linearity Comments

  22. read as a function of socst(adjusted femaleses)

  23. math as a function of science(adjusted femaleses)

  24. Fractional polynomial models are a simple yet very useful extension of linear functions and ordinary polynomials If you are willing to do some straightforward do-file programming, you can apply them in a bespoke manner to a wide range of Stata regression-type commands and get useful results For (much) more, see Royston & Sauerbrei (2008) book Conclusions

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