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ICON plc 27 th September 2006

ICON plc 27 th September 2006. Forward Looking Statements.

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ICON plc 27 th September 2006

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  1. ICON plc27th September 2006

  2. Forward Looking Statements Certain statements contained herein including, without limitation, statements containing the words “believes,” “anticipates,” “intends,” “expects” and words of similar import, constitute forward-looking statements concerning the Company's operations, performance, financial condition and prospects. Because such statements involve known and unknown risks and uncertainties, actual results may differ materially from those expressed or implied by such forward-looking statements. Given these uncertainties, prospective investors are cautioned not to place undue reliance on such forward-looking statements. The Company undertakes no obligation to publicly update or revise any forward-looking statements, whether as a result of new information, future events or otherwise.

  3. Investment Highlights Top global CRO Strong market fundamentals Outstanding record of organic growth Strong balance sheet Growth accelerating Margins expanding

  4. Company Overview • Approx. $430 million in annualized net revenues • 6 Year Net Revenue CAGR = 30% • 4th Largest CRO in Phase II – IV • Global coverage - 45 locations in 30 countries • Unique operating model with focus on quality and flexibility • > 3,700 staff worldwide • Note Change of Year End to 31 December

  5. Global Reach: EU – 16 Offices Stockholm Marlow Amsterdam Vilnius Manchester Riga Dublin Warsaw Moscow Eastleigh Milan Barcelona Tel Aviv Paris Budapest Frankfurt www.iconclinical.com

  6. Global Reach – USA – 15 Offices Salt Lake City Chicago San Francisco Doylestown Irvine New York City Long Island Houston Philadelphia San Diego Delaware Nashville Baltimore Tampa Raleigh-Durham www.iconclinical.com

  7. Offices: ROW – 15 Offices Montreal Seoul Sydney Beijing Sao Paulo Bangkok Mexico City Tokyo Hong Kong Santiago Taiwan Chennai Buenos Aires Singapore www.iconclinical.com Johannesburg

  8. Global Full Service Clinical Development 5% Drug Development and Regulatory Support 4% Phase I 58% Trial Management, Monitoring & Pharmacovigilence 13% Data Management & Statistical Consulting 5% Interactive Technologies 10% Central Laboratory 3% Central Imaging Lab 2% Contract Staffing

  9. Market Environment

  10. Fundamental R&D Spending Growth Trend ~ 6%- 8% p.a. Phase II / III pipelines strengthening Increased Outsourcing Growth c.15% p.a. since 2001* Being accelerated by activity & funding in Biotech / Speciality Evidence emerging that projects where CROs are engaged complete faster than “internal only” studies* Regulatory Environment Globalisation favouring large CROs Strong Market Environment with... *Source: Tufts Centre for Study of Drug Development

  11. …US Biotech Funding Environment continuing to grow, leading to... Biotech fund raising ($billions) $Billion Source: Burrill and Company

  12. …strong RFP growth at ICONRFP Volume / Value Trends – Global Clinical 2005 Growth H1 2006 Growth

  13. ICON Gross Business Wins - Last 8 Quarters ($ millions)

  14. ICON’s Net New Business Wins growing strongly… Net Business Wins Book to Bill Ratio

  15. …leading to record total backlog levels ($ millions)

  16. …and strong forecast coverage of next 4 quarters revenues. Value of backlog forecast to be earned in next 4 quarters % coverage of next 4 quarters forecast revenues

  17. Improving Client Concentration

  18. Strategy

  19. ICON’s Broad Strategy Capitalise on market fundamentals to drive organic growth. Expand geographic footprint Pursue acquisitions to enhance depth and scale of current operations and to add additional complementary services Cross-sell services to grow sales and margin

  20. Cross-sell to leverage client relationships and capture more of the project spend. Strategic Product Development / Consulting 5% Phase I 4% Central Laboratory 10% Central Imaging Lab 3% Clinical Trial Management Phase II – IV 58% IVRS 5% Data Management & Biostatistics 13% Contract Staff 2%

  21. Examples of some detailed strategic initiatives Creating Therapeutic Specialist Groups (TAGs) in key therapeutic areas to leverage our experience and build further scale e.g. Oncology Investing in Operations in Japan – significant opportunity for growth over next 10 years Creation of Data Management Operation in India – circa 100 people and growing Partnership with Medidata Solutions in EDC – gaining traction Developing specialised Phase IV Division and acquisition of Ovation

  22. Financial Performance

  23. Recent Financial Performance ($ millions, except EPS)

  24. Recent Financial Performance ($ millions, except EPS)

  25. Net Revenue CAGR of 30% over last 6 Years, and strong growth forecast for 2006 CAGR 30% * *Mid point calendar year guidance issued July 26, 2006

  26. Revenue Growth v Peers: Net Revenue CAGR between 2000 and 2005 *Source SEC Filings

  27. 2006 forecast growth is underpinned by strong forecast coverage of next 12 months revenues. (US$, & % of Forecasts)

  28. Earnings Per Share Growth (E) * *Mid point guidance issued July 26, 2006 before FAS123R Stock Compensation

  29. Summary Balance Sheet and Cash Flow ($ millions)

  30. Improving Margins

  31. Quarterly Operating margins have been improving….

  32. … driven by expanding Clinical margins as revenue growth has accelerated, and…….

  33. …..Lab returning to profit in Q2…. Lab Results

  34. …As Lab revenues grew strongly (at last!) …. $ millions

  35. …driven by strong Lab net new business wins Net Business Wins Book to Bill Ratio

  36. Investment Highlights Top global CRO Strong market fundamentals Outstanding record of organic growth Strong balance sheet Growth accelerating Margins expanding

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