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BioGinkgo 27/7. Proprietary extract of ginkgo leaves Addresses #2 concern among aging baby boomers Loss of memory. A 100 Yr. Old Bonsai Ginkgo Tree. Ginkgo biloba L. plant: History. Oldest living plant species, nick named “living fossil”. In China, it is called “thousand-year-old tree”
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BioGinkgo 27/7 • Proprietary extract of ginkgo leaves • Addresses #2 concern among aging baby boomers • Loss of memory A 100 Yr. Old Bonsai Ginkgo Tree
Ginkgo biloba L. plant: History • Oldest living plant species, nick named “living fossil”. In China, it is called “thousand-year-old tree” • Described in the ancient Chinese pharmacopoeia- Shen nown Ben Cao • Since 1960s, Ginkgo biloba extract is the most widely used herb in Europe
Ginkgo biloba L. leaf: History, cont’d • Pharmanex scientific advisor, Prof. Koji Nakanishi, Columbia University: Discovered a class of unique ginkgolides in ginkgo plant • Ginkgolides can increase blood flow by blocking PAF, a substance that causes platelet clumping
BioGinkgo 27/7: Uniqueness • Pharmanex extraction process enriches for ginkgolides • Only Ginkgo extract that provides for adequate and persistent amounts of ginkgolides in the blood
12 10 8 6 4 2 0 Blood concentration of ginkolides after oral intake of BioGinkgo 27/7 or Ginkoba BioGinkgo 27/7 Ginkoba Ginkgolide levels (µg/ml) 30 minutes 12 hours Published in Planta Medica
BioGinkgo 27/7 - Attributes • Unique formulation of enriched for levels of ginkgolides • Improved bioavailability compared to competitors • Undesirable Ginkgolic acids removed • One of the few companies to manufacture its own ginkgo product
Selected leaves 1. crushed 2. aq. Alcohol extract 3. precipitation 4. chromatography 5. remove Ginkgolic acids 6. drying Flavone-lactone mixture QA/QC Finished bulk preparation Bioginkgo 27/7 process scheme
Ginkgo biloba Extract: Cerebral Insufficiency Taillander et al. Presse Med. 1986 15 1583-1587 • 12-month placebo controlled trial of 210 elderly patients • Ave. age 82 years • End points: Symptoms scale including dizziness, tinnitus, headaches, lack of energy, and difficulties in memory and concentration at 3, 6, 9, and 12 months Time of assessment Treatment 3 6 9 12 months Placebo 4% 4% 8% 8% Ginkgo 10% 15% 15% 17%
JAMA clinical study • A Placebo-Controlled, Double-blind, Randomized Trial • A 52-week multi-center study • Patients: Outpatients with Alzheimer disease or multi-infarct dementia, without other significant medical conditions.
JAMA clinical study: Study Design • Complete outcome evaluation at 12, 26, and 52 weeks. • Primary Outcome Measures. Alzheimer's Disease Assessment Scale-Cognitive subscale (ADAS-Cog), Geriatric Evaluation by Relative's Rating Instrument (GERRI), and Clinical Global Impression of Change (CGIC).
JAMA clinical study: Conclusions • Ginkgo group score better than placebo in ADAS-Cog and GERRI score • No difference in the Clinical Global Assessment Index • Ginkgo was safe • Appears capable of stabilizing and improving the cognitive performance and the social functioning of patients for 6 months to 1 year.
BioGinkgo 27/7: summary • BioGinkgo enhances blood circulation to brain, arms, legs • Mechanism of action believed to be related to flavonoids and ginkgolides • BioGinkgo is recommended to be taken one tablet twice a day
Introducing…Bio St. John’s Standardized St. John’s wort to 0.3% hypericin (Hypericum perforatum) PLUS CordyMax Cs-4 [Patent Pending] (Cordyceps sinensis) Each capsule of Bio St John’s contains 375 mg of CordyMax and 225 mg St John’s wort extract. The daily recommended dosage is two capsules twice a day.
Bio St. John’s : Claims • Stabilizes mood and promotes a positive outlook • Provides vitality and stamina • Reduces fatigue without stimulants
Bio St. John’s: Benefits • Bio St. John’s is not a substitute for prescription anti-depressant drugs
St. John’s Wort: Brit. Medical Journal Study • Meta-Analysis (BMJ, 1996) • 23 randomized trials with 1,757 patients • % patients respond to treatment • SJW (55.1%) vs Placebo (22.3%) • SJW (63.9%) vs Antidepressant (58.5%) • Test on mild/moderate depression • major depression or manic depressive disorder not tested
Putative mechanisms of action • Monoamine oxidase inhibition • Selective serotonin-reuptake inhibition • Inhibition of catechol O-methyltransferase • GABA and neurokinin receptors Overall outcome: Effect on neurotransmitters function
St. John’s wort : Safety/Possible side effects Most common adverse effects are: • GI symptoms • Tiredness/sedation • Dizziness/confusion • Photosensitivity, but this appears to occur rarely
Age Efficacy with age Before St.John’s wort After St.John’s wort
Bio St. John’s • A combination of St. John’s wort and CordyMax • The recommended dose for Bio St John’s is 4 capsules daily • It is not a replacement for prescription anti-depressants