1 / 21

BioGinkgo 27/7

BioGinkgo 27/7. Proprietary extract of ginkgo leaves Addresses #2 concern among aging baby boomers Loss of memory. A 100 Yr. Old Bonsai Ginkgo Tree. Ginkgo biloba L. plant: History. Oldest living plant species, nick named “living fossil”. In China, it is called “thousand-year-old tree”

Download Presentation

BioGinkgo 27/7

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. BioGinkgo 27/7 • Proprietary extract of ginkgo leaves • Addresses #2 concern among aging baby boomers • Loss of memory A 100 Yr. Old Bonsai Ginkgo Tree

  2. Ginkgo biloba L. plant: History • Oldest living plant species, nick named “living fossil”. In China, it is called “thousand-year-old tree” • Described in the ancient Chinese pharmacopoeia- Shen nown Ben Cao • Since 1960s, Ginkgo biloba extract is the most widely used herb in Europe

  3. Ginkgo biloba L. leaf: History, cont’d • Pharmanex scientific advisor, Prof. Koji Nakanishi, Columbia University: Discovered a class of unique ginkgolides in ginkgo plant • Ginkgolides can increase blood flow by blocking PAF, a substance that causes platelet clumping

  4. BioGinkgo 27/7: Uniqueness • Pharmanex extraction process enriches for ginkgolides • Only Ginkgo extract that provides for adequate and persistent amounts of ginkgolides in the blood

  5. 12 10 8 6 4 2 0 Blood concentration of ginkolides after oral intake of BioGinkgo 27/7 or Ginkoba BioGinkgo 27/7 Ginkoba Ginkgolide levels (µg/ml) 30 minutes 12 hours Published in Planta Medica

  6. BioGinkgo 27/7 - Attributes • Unique formulation of enriched for levels of ginkgolides • Improved bioavailability compared to competitors • Undesirable Ginkgolic acids removed • One of the few companies to manufacture its own ginkgo product

  7. Selected leaves 1. crushed 2. aq. Alcohol extract 3. precipitation 4. chromatography 5. remove Ginkgolic acids 6. drying Flavone-lactone mixture QA/QC Finished bulk preparation Bioginkgo 27/7 process scheme

  8. Chemical fingerprint of ginkgolide terpene lactones

  9. Ginkgo biloba Extract: Cerebral Insufficiency Taillander et al. Presse Med. 1986 15 1583-1587 • 12-month placebo controlled trial of 210 elderly patients • Ave. age 82 years • End points: Symptoms scale including dizziness, tinnitus, headaches, lack of energy, and difficulties in memory and concentration at 3, 6, 9, and 12 months Time of assessment Treatment 3 6 9 12 months Placebo 4% 4% 8% 8% Ginkgo 10% 15% 15% 17%

  10. JAMA clinical study • A Placebo-Controlled, Double-blind, Randomized Trial • A 52-week multi-center study • Patients: Outpatients with Alzheimer disease or multi-infarct dementia, without other significant medical conditions.

  11. JAMA clinical study: Study Design • Complete outcome evaluation at 12, 26, and 52 weeks. • Primary Outcome Measures. Alzheimer's Disease Assessment Scale-Cognitive subscale (ADAS-Cog), Geriatric Evaluation by Relative's Rating Instrument (GERRI), and Clinical Global Impression of Change (CGIC).

  12. JAMA clinical study: Conclusions • Ginkgo group score better than placebo in ADAS-Cog and GERRI score • No difference in the Clinical Global Assessment Index • Ginkgo was safe • Appears capable of stabilizing and improving the cognitive performance and the social functioning of patients for 6 months to 1 year.

  13. BioGinkgo 27/7: summary • BioGinkgo enhances blood circulation to brain, arms, legs • Mechanism of action believed to be related to flavonoids and ginkgolides • BioGinkgo is recommended to be taken one tablet twice a day

  14. Introducing…Bio St. John’s Standardized St. John’s wort to 0.3% hypericin (Hypericum perforatum) PLUS CordyMax Cs-4 [Patent Pending] (Cordyceps sinensis) Each capsule of Bio St John’s contains 375 mg of CordyMax and 225 mg St John’s wort extract. The daily recommended dosage is two capsules twice a day.

  15. Bio St. John’s : Claims • Stabilizes mood and promotes a positive outlook • Provides vitality and stamina • Reduces fatigue without stimulants

  16. Bio St. John’s: Benefits • Bio St. John’s is not a substitute for prescription anti-depressant drugs

  17. St. John’s Wort: Brit. Medical Journal Study • Meta-Analysis (BMJ, 1996) • 23 randomized trials with 1,757 patients • % patients respond to treatment • SJW (55.1%) vs Placebo (22.3%) • SJW (63.9%) vs Antidepressant (58.5%) • Test on mild/moderate depression • major depression or manic depressive disorder not tested

  18. Putative mechanisms of action • Monoamine oxidase inhibition • Selective serotonin-reuptake inhibition • Inhibition of catechol O-methyltransferase • GABA and neurokinin receptors Overall outcome: Effect on neurotransmitters function

  19. St. John’s wort : Safety/Possible side effects Most common adverse effects are: • GI symptoms • Tiredness/sedation • Dizziness/confusion • Photosensitivity, but this appears to occur rarely

  20. Age Efficacy with age Before St.John’s wort After St.John’s wort

  21. Bio St. John’s • A combination of St. John’s wort and CordyMax • The recommended dose for Bio St John’s is 4 capsules daily • It is not a replacement for prescription anti-depressants

More Related