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Stop Smoking With Hypnotherapy Study. A Proposal. Bupropion studies. 615 smokers – randomised to drug 100mg, 150mg, 300mg or placebo for 7 weeks Try to stop at 1 week For 300 mg - at 7 weeks[course end] 10.5% stop with placebo 24.4% stop with drug
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Stop Smoking With Hypnotherapy Study A Proposal
Bupropion studies • 615 smokers – randomised to drug 100mg, 150mg, 300mg or placebo for 7 weeks • Try to stop at 1 week • For 300 mg - at 7 weeks[course end] • 10.5% stop with placebo • 24.4% stop with drug • At one year point prevalence [ no smoking for last week] • 12.4% placebo • 23.1% drug
Bupropion studies • 893 smokers one of 4 treatments for 9 weeks – 12 month point prevalence • Placebo oral + placebo patch 15.6% • Bupropion 300mg + placebo patch 30.3% • Nicotine patch + oral placebo 16.4% • Bupropion 300mg + nicotine patch 35.5%
Bupropion studies • Continuous absence rates = • Bupropion alone 18.4% • Bupropion +patch 22.5% • Cost • £86 + counselling – 5 sessions
Bupropion studies • Problems with Bupropion • 11% dry mouth • 42% insomnia • 6% hypertension { if given with patch} • 1:1000 - fitting
Bupropion studies • Contraindications • Epilepsy • Pregnancy • History of fits • History of head injury • Diabetes on drugs or insulin • Patients on • Theophylline Systemic steroids • Antipsychotics • Antidepressants
Hypnotherapy Studies • Hypnotherapy • Safe • Specific • Difficult to generalise • Few published single session studies
Hypnotherapy Studies • 226 Smokers [ Spiegel Frishholz Spiegel] • Single session treatment • 2 year follow up • 53% stop at one week • 23% stop at two years
Hypnotherapy Studies • 40 patients [Berkowitz Townsend Kohberger] • Single session • 25% stop at 6/12
Hypnotherapy Studies • LCCH method • Single sessions • Cost £ 150 approx • Easily learned • No side effects • Does it work ??
Hypnotherapy Studies • LCCH study • Single hypnotherapist • LCCH method • One hour session only • Follow up one month to one year • Postal Questionnaire
LCCH Study Results • 59 questionnaires sent { follow up 1/12 to 1 yr } • 35 Returned 59.3% • Of those returned • 30 stopped 85% • 1 cut down 2.8% • 4 continued unchanged 11..4% • At one month • 23 stay stopped 65.7%
LCCH Study Results • Results beyond this unsatisfactory due to lack of follow up • BUT no known restarters after 6 months • Restarters • 3 at less than one month • 4 at 1-3/12 • 2 at 4-6/12 • We have a definite 12 stopped at one year { 34% } but as data is incomplete • Could presume 21 stopped at one year which would be 60% stop at one year
Hypnotherapy Proposal • Randomised study - Possible Studies • In conjunction with Community Stop Smoking Clinics • Single session LCCH method hypnotherapy Vs Bupropion + counselling • Possible arms • Single session hypnotherapy • Single session hypnotherapy + NRT • Single session hypnotherapy + Bupropion • Bupropion + counselling