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Sickle Cell Anemia. By Alex Lange & Roy Darrah. Inheritance Pattern. Parents can be carriers and show no symptoms of the disease. Sickle Cell Anemia is a autosomal reccesive pattern. Mutations. Mutations in the HBB gene causes Sickle Cell Anemia.
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Sickle Cell Anemia By Alex Lange & Roy Darrah
Inheritance Pattern Parents can be carriers and show no symptoms of the disease. • Sickle Cell Anemia is a autosomal reccesive pattern.
Mutations Mutations in the HBB gene causes Sickle Cell Anemia. It consists of four protein subunits, 2 alphaglobins and 2 betaglobins which form a hemoglobin (C,E,S,AS). Hemoglobins bind oxygen in a cell, but amino acids can switch with betaglobins making the cell nonfunctional.
Incidences • Sickle Cell Anemia is most common in people with African, Mediterranean, and Caribbean ancestors. • Sickle Cell Anemia is most common inherited blood disorder in the US, 70-80 thousand Americans have this disorder. • 1 in 500 African Americans and 1 in 1000 Hispanic Americans will have this disorder.
Symptoms • Shortness of breath • Fatigue • Delayed growth in children • Yellowing of the eyes and skin • Cells can get stuck in veins • Organ damage (lungs, kidneys, spleen, brain) • High blood pressure
Treatments • There is no cure to Sickle Cell Anemia except for a bone marrow transplant.
Lifetime Limitations • People can live normal lives • Others should avoid a lot of physical activity due to the lack of oxygen and cells • Stay away from high altitudes • Ryan Clark plays football for the Steelers and he has Sickle Cell Anemia. Even though he struggles with extreme exercises and hypoxia from high altitudes.
