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ASD

ASD. Dr. H. Sadeghian. ASD ostium secondum: in the central portion of Atrial septum in the position of foramen ovalis Sinus venosus: in the region of SVC, RA junction or IVC RA junction Unroofing coronary sinus: between ostium of CS to RA and LA

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ASD

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  1. ASD Dr. H. Sadeghian

  2. ASD ostium secondum: in the central portion of Atrial septum in the position of foramen ovalis • Sinus venosus: in the region of SVC, RA junction or IVC RA junction • Unroofing coronary sinus: between ostium of CS to RA and LA septum primum and endocardial cushion defect 4. ASD ostium primum Rudolph chapter 7

  3. Sinus venosus : 3 – 10% ASD ostiom serondun: more common F / M = 2/1 5% ASD + PS (valvuler) Muller, chapter 22

  4. PVR abn < 10% AsD ostium secondum almost always ASD SV Associates PVRAb Braunwald

  5. Morphologic and Embriologic considerations Septum primum grows from posterosuperior side (SVC side) toward A-V junction where endocardial cushion separotes Atria from ventricles. The lower part of the septum primum is completed by fusion with endocardial cushion tissue. Rudolph chapter 7

  6. Some fenestrations develop in midportion of septum primum. Septum secrodum just grows in the posterosuperior portion of IAS (near SVC) but right to the septum primum. It grows toward the AV junction and it partly covers the central hole of septum prinum. It has a semilunar edge which is concave toward TV. Rudolph chapter 7

  7. Ostium secondum defects • Large hole in septum primum or • Inadequite development of septum secondum Rudolph chapter 7

  8. Sinus venosus defects: septum primum or secondum • Unroofing CS: the well between CS and LA, may involved a portion of septum or whole septum and are frequently associated with LPSVC Rudolph chapter 7

  9. LAP 1-2 mmHg >RAP two ventricles fill with one pressure so RV will be distended. Rudolph chapter 7

  10. The degree of left to right Shout depends on the 1- The size of the defect 2- Filling pressure of ventricles Braunwald

  11. Infants Large defects: QP/Qs > 2.5 : 1  Produce symptoms Medium size defects: do not cause symptoms during infancy and early childhood Rudolph chapter 7

  12. ASD beyond infancy The majority of children even those with large defeats do not experience symptoms. Unlike VSD most of them tend to be smaller with growing, ASD usually grows in proportion to heart size and there is evidence suggesting that some defects may become larger as age increase. Rudolph chapter 7

  13. 40% ASDs in infants will close spontonously ASD < 3 mm in first 3 months  always close ASD > 8 mm is unlikely to close Muller, chapter 22

  14. Spontanous closure of ASD may occur within the 1 year of life. < 7 mm in neonatal period may reduce in size and require no intervention Braunwald

  15. Natural history of growth of ASD ostiun secondum and implication Heart 2002, 87, 256-9

  16. 104 Patients Exclusion criteria: multiple ASDs or fenestrated 91 – 98 3 – 6 mm small ASD  6 – 12 moderate  12 large 65% patients  size with ASD 30% > 50% increase in size spontanous closure in 4 patients 12%  20 mm Only factor associated with ASD growth was initial size Heart 2002, 87, 256-9

  17. ASD growth was independent of age of patients Conclusion: 2/3 of ASDs growth with time Heart 2002, 87, 256-9

  18. Defects < 6 mm 66% spontanous closure Mean age of diagnosis: 4.5 years F / M / 2.2/1 Heart 2002, 87, 256-9

  19. Small ASD group 33% had small defects(34P) FO 3p closed spontounsly 26% (27p) ASD 1 small  mod 3 small  large 1.6 mm/y  size Mean FO : 3.2 y Heart 2002, 87, 256-9

  20. Mod ASD group 40 p (38%) FO 31% mod 3  small 8  large 1.6 mm/y  mean FO: 3.3 y Heart 2002, 87, 256-9

  21. Large ASD defeats 30 p (29%) large 43% (45) FO : large 1.9 mm/y FO : 2.9 year Heart 2002, 87, 256-9

  22. 66%  ASD size 14% decrease 20% no change Initial size, final size correlated Heart 2002, 87, 256-9

  23. The main concerns in individuals with ASD are • PV Resistance • Atrial arrhythmia • Cardiac failure Rudolph chapter 7

  24. The association of PVD and ASD are infrequent during childhood. Singificant PVD is unusual before age of 25-30 years. Beyond this age, PVD occurred in 5-10% ASDs and is related to high altitude PVD f/M : 2 : 1 Altitude > 4000 ft PVD in earlier ages Rudolph chapter 7

  25. PVR PVR in ASD usually is normal , 1 unit / m2 3  considerable Rudolph chapter 7

  26. Atrial arrhythmia Af , Flutter , PAT occurs commonly in older patients. They are probably related to large shunts. < 20 y 1 - 2% > 20 y 15 - 50% Rudolph chapter 7

  27. Cardiac failure >20 y , Right sided Failure Rudolph chapter 7

  28. ECG SV defects: P ware  0 AV may be moderately prolonged with large defects QRS Axis: RAD (90 to 180) rsR or rSR , incomplete RBBB R in right precordial 10 – 15 mm >  PVD Rudolph chapter 7

  29. Negative P in Inferior leads  ASD SV below SVC Braunwald

  30. Echo • RV Enlargement • QP/QS • PVR , SVR • PAP , TR , PAPm , d • RV function Rudolph chapter 7

  31. Subcostal : bicaval

  32. Pressures 15 – 30 mmHg Pressure RV-PA 10 – 15 mmHg MPA , branches Rudolph chapter 7

  33. 30% of the patients have effort dyspnea in third decade and more than 73% by fifth decade Braunwald

  34. SV arrhythmia and RSF 10%> 40y Paradoxical embolic may occur Braunwald

  35. Cyanosis 1- Isenmenger 2- Prominent eustachien valve which leads IVC flow to ASD 3- ASD SV below IVC Braunwald

  36. Management Large ASD QP/Qs < 2 : 1 QP/QS < 1.5 : 1  Follow up Rudolph chapter 7

  37. Indications for Intervention The presence of RSF + ASD > 5 mm with no sign of spontaneous closure 18 month 3/4 ASDs may close spontaneously Muller and Hoffman

  38. QP QS < 1.5 : don’t want Closure except for paradoxical emboli Braunwald

  39. Significant ASD : QP / QS > 1.5 : 1 Or RV volume overload  intervention P HTN : PAP > 2/3 systemic Or PVR > 2/3 SVR 1- QP / QS > 1.5 / 1  2- Challenge to O2 or No 3- Lung biopsy  reversibility  ASD closure Braunwald

  40. Device closure Stretch diameter < 41 mm Adequate rim Complications : embolization thronbus formation < 1% atrial perforation Comparing surgery to device closure : 1- better preservation RV function 2- lower complication rate Braunwald

  41. Surgery - Sinus venosus - Ostium primum - Ostium serondum not suitable for device closure Mortality < 1% Braunwald

  42. ASD with P HTN PVR > 8 – 12 unit / m2 : high mortality PVR > 12 unit / m2 FO PVR 4 – 8 unit / m2 mortality 10% Rudolph chapter 7

  43. After device closure - Aspirin 6 mouths - Prophylaxis of IE 6 mouths Braunwald

  44. Long surveillance 1- ASD SV : Caval or PV stenosis 2- RV Failure 3- Atrial arrhythmia Braunwald

  45. < 10% ASD PHTN PPHTN in association with ASD > 50% patients > 45y AF Muller, chapter 22

  46. Post op Atrial arrhythmia Soon after surgery to later years 30 – 50% incidence PAT , AF and flutter but brady-tachy arrhythmia  pace Transcatheter closure  incidence arrhythmia? Rudolph chapter 7

  47. AF 25% patients > 20 y 5% patients < 20 y Late post operative arrhythmia : 2 - 9 % children 2 - 33% adults Early after repair : 14% Atrial arrhthmia espicially in SV defects Muller

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