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A. mmu-miR-34a-5p mmu-mir-34a-3p. hsa-miR-34a-5p hsa-miR-34a-3p. dre-miR-34. dme-miR-34-5p dme-miR-34-3p. mmu-miR-34b-5p mmu-miR-34b-3p. hsa-miR-34b-5p hsa-miR-34b-3p. dre-miR-34b. dre-miR-34c. mmu-miR-34c-5p mmu-miR-34c-3p. hsa-miR-34c-5p hsa-miR-34c-3p. B. miR-34a. miR-34b.
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A mmu-miR-34a-5p mmu-mir-34a-3p hsa-miR-34a-5p hsa-miR-34a-3p dre-miR-34 dme-miR-34-5p dme-miR-34-3p mmu-miR-34b-5p mmu-miR-34b-3p hsa-miR-34b-5p hsa-miR-34b-3p dre-miR-34b dre-miR-34c mmu-miR-34c-5p mmu-miR-34c-3p hsa-miR-34c-5p hsa-miR-34c-3p B miR-34a miR-34b miR-34c Suppl. Fig. 1 : Evolution of miR-34 sequence in Drosophila, Zebrafish, Mouse and Humans. (A) Various isoforms of miR-34 in different species during evolution (B) The degree of conservation as shown by multiple sequence alignment using CLUSTALW for the various isoform of mature miR-34 in the four species mentioned above. Nomenclature as per miRBase version 19.