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pH4

Molecular Design and Nanomechanical Properties of Comb-Type Graft Copolymers Christine Ortiz (MIT), DMR 0094194.

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pH4

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  1. Molecular Design and Nanomechanical Properties of Comb-Type Graft CopolymersChristine Ortiz (MIT),DMR 0094194 The goal of this research program is to explore the potential of comb-like graft copolymers for use in control of nanomechanical and interfacial properties. [1-4]. One example is the synthesis of stimulus (pH)-responsive thiol-terminated poly(methacrylic acid-g-ethylene glycol)s of varying macromolecular architectures which were then chemically end-attached to surbstrates and tested nanomechanically. The results demonstrate a reversible switching of the nanoscale intersurface potential from net repulsive (high pH) to net attractive (low pH). Such systems have great promise in a variety of applications including, for example; drug delivery, transport, separation, and detection of biomolecules, directed cellular function, and controlled adhesion, friction, and lubrication in microfluidics. pH4 pH6 pH9 (Top) Nanomechanical data for stimulus responsive poly(methacrylic acid-g-ethylene glycol) and (Bottom) atomic force microscope images of conformational transition 1) Macromolecules 38; 2535 2005. 2) Macromolecules 38; 2530 2005. 3) Macromolecules 2004 37 4271. 4)Y e et al. submitted to Soft Matter 2005.

  2. Molecular Design and Nanomechanical Properties of Comb-Type Graft CopolymersChristine Ortiz (MIT),DMR 0094194 • Outreach • Hosted one junior undergraduate from Michigan State University, Ellie Rahbar, for Summer 2005 as part of the MIT minority summer research program • Hosted one junior undergraduate from Cornell University, Alex Hu, for Summer 2005 as part of the MIT Biotechnology Process Engineering Center • Participated in MITES (Minority Introduction to Engineering, Entrepreneurship, and Science) for high school students • Developed laboratory for Keys to Empowering Youth (KEYs) Program as part of a day-longhigh school conference entitled Women in Science and Engineering (WISE). Education ● Under this grant, one graduate student is pursuing his Ph.D. degrees: Mr. Miao Ye (3rd year) and two undergraduate students have also worked on this project (Jonathon Tejada and Jane Yoon). ● The PI, Christine Ortiz taught a one-week nanomechanics short course (lectures and laboratories) for graduate students at the Universidad de Chile, Santiago, Chile Summer 2005. U. Chile Miao Ye Jonathon Tejada Jane Yoon

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