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CASP9. mTOR. CDKN1A. BAD. CHUK. CDKN1B. FOXO1. MDM2. GSK3B. PDE3A/B. NOS3. Growth factor. GFR (e.g. ERBB2).
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CASP9 mTOR CDKN1A BAD CHUK CDKN1B FOXO1 MDM2 GSK3B PDE3A/B NOS3 Growth factor GFR (e.g. ERBB2) miR-203; miR-106/302; miR-10; miR-148/152; miR-155; miR-19; miR-124/506; miR-132/212; miR-124/506; miR-122; miR-203; miR-143; miR-142-3p; miR-25/32/92/92ab/363/367; miR-33/33ab; miR-129/129-5p; miR-24 miR-26ab/1297; miR-148/152; miR-103/107; miR-19; miR-425/489; miR-29abc; miR-130/301; miR-25/32/92/92ab/363/367; miR-23ab; miR-141/200a; miR-338/338-3p; miR-132/212; miR-22; miR-144; miR-17-5p/20/93.mr/106/519.d; miR-205; miR-139-5p; miR-181; miR-200bc/429; miR-365; miR-216/216a; miR-214/761; miR-10; miR-153; miR-193ab; miR-183; miR-106/302; miR-194; miR-490/490-3p; miR-217; miR-129/129-5p miR-21 PI3K PTEN PIP3 miR-214/761; miR-490/490-3p; miR-218; miR-125/351; miR-24; miR-31; miR-128; miR-124/506; miR-141/200a miR-130/301; miR-96/1271; miR-128; miR-138; miR-216/216a; miR-139-5p; miR-148/152; miR-155; miR-143; miR-27ab; miR-137; miR-181; miR-150; miR-425/489; miR-7/7ab; miR-129/129-5p; miR-22; miR-140/140-5p/876-3p; miR-187; miR-216/216b; miR-9; miR-182; miR-125/351; miR-205; miR-375; miR-25/32/92/92ab/363/367; miR-33/33ab; miR-19; miR-133; miR-23ab; miR-24 PDK1/2 miR-106/302; miR-138; miR-183; miR-338/338-3p; miR-143; miR-22 AKT miR-182; miR-96/1271; miR-155; miR-146; miR-130/301; miR-193ab; miR-7/7ab; miR-10; miR-140/140-5p/876-3p; miR-124/506; miR-223 miR-221/222; miR-26ab/1297; miR-208/208ab; miR-499/499-5p; miR-10; miR-194; miR-24 miR-17-5p/20/93.mr/106/519.d; miR-365; let-7/98; miR-130/301; miR-208/208ab; miR-499/499-5p; miR-132/212; miR-22; miR-101; miR-124/506; miR-148/152; miR-199/199-5p; miR-15/16/195/424/497; miR-141/200a; miR-145 miR-106 miR-153; miR-129/129-5p; miR-490/490-3p; miR-34a/34b-5p/34c/34c-5p/449/449abc/699 miR-223; miR-96/1271; miR-135; miR-101; miR-128; miR-27ab; miR-21/590-5p; miR-183;miR-132/212; miR-26ab/1297; miR-145; miR-216/216a; miR-15/16/195/424/497; miR-196ab; miR-129/129-5p; miR-144; miR-143; miR-182; miR-200bc/429; miR-338/338-3p; miR-142-3p; miR-204/211; miR-194; miR-139-5p; miR-490/490-3p; miR-9; miR-216/216b; miR-221/222; miR-153; miR-133; miR-218; miR-365 miR-221/222; miR-150; miR-24; miR-200bc/429; miR-196ab; miR-190; miR-218; miR-199/199-5p; miR-148/152; miR-181; miR-194; miR-155; miR-34a/34b-5p/34c/34c-5p/449/449abc/699; miR-141/200a; miR-153; miR-455/455-5p; miR-122; miR-223; miR-129/129-5p miR-26ab/1297; miR-199/199-5p miR-23ab; miR-148/152; miR-15/16/195/424/497; let-7/98; miR-208/208ab; miR-499/499-5p; miR-223; miR-21/590-5p; miR-133; miR-130/301; miR-425/489 miR-144; miR-96/1271; miR-7/7ab; miR-99ab/100; miR-135; miR-101; miR-375; miR-128; miR-103/107 miR-31; miR-155; miR-124/506; miR-34a/34b-5p/34c/34c-5p/449/449abc/699 PDE3A: miR-128; miR-139-5p; miR-138; miR-216/216b; miR-27ab; miR-21/590-5p; miR-155; miR-204/211; miR-218; miR-210 PDE3B: miR-205; miR-33/33ab; miR-15/16/195/424/497; miR-103/107; miR-17-5p/20/93.mr/106/519.d; miR-27ab; miR-181; miR-9; miR-144; miR-153; miR-214/761; miR-223; miR-425/489; miR-499/499-5p; miR-25/32/92/92ab/363/367; miR-141/200a; miR-128 Supplemental Figure 1. Overview of Akt signaling. Summary of Akt signaling and predicted miRNA interactions. miRNAs that were described to be downregulated in prostate cancer are highlighted in green, while upregulated miRNAs are highlighted in red; all other potential interactions are highlighted in black. Target interactions were predicted with TargetScan 5.1. miRNAs presented in this figure are all highly conserved among vertebrates; for a list of other miRNAs see Supplemental Table 1.