First Lego League F.L.L

1. First Lego League F.L.L • Each year the contest focuses on a different real-world topic related to the sciences. • This year’s project topic: Biomedical (combining engineering and medical) • The robotics part of the competition revolves around designing and programming Lego robots to complete all tasks in 2 ½ minutes.

2. Thank you • The F.L.L competition in Lee’s Summit at Summit Lakes Middle School is sponsored by family and friends of Stephanie Bentele • She was the district science administrator who passed away from the flu in 2008.

3. Syringe to base - 25 White blood cells to patient area - 15 Open artery walls with stint - 25 Cardiac patch in heart - 20 Black part of pacemaker in heart (NO GRAY) - 25 Set off mechanical hand - 25 Push blue and white off of medicine dispenser (leave pink) - 25 Push pressure tester - 25 Push red part of brain - 15 Open brain door - 20 People to patient area - 25 Black sides of panels facing north – 25 OR Up - 20 Repair big bone - 15 Kick ball into goal - 25 Bionic eyes touching hands/ arms of big person on mat - 20 Push small bone together/ put cast on small bone – 25 Blue and white pills to patient area - 5 Missions & Point Values

4. Mission: Push, Push, Push

5. Mission: Insert Stent

6. Mission: Insert Heart Patch and Pacemaker

7. Mission: White Blood Cells into the Big Bone

8. Mission: Bring Dr. and Syringe back to base

9. Mission: Get People to Patient Area

10. The Biomedical Project Rheumatoid Arthritis These are the steps we took • Select a topic • Research • Chose a problem to solve • Create a solution • Prepare to present our solution Leukemia Scoliosis

11. Rheumatoid Arthritis Rheumatoid Arthritis is a disease that causes swelling, inflammation, and stiffness in the joints. By Jack P, Jack V, Bryce M, and Dawson S

12. Causes • Exact cause is unknown • Hereditary • A marker (HLA-DR4) gives you a higher chance to get RA if you have it

13. Symptoms • Joint pain, swelling, and stiffness; decreased range of motion: fever, fatigue and loss of energy can also occur • Swelling in pairs of joints—especially smaller ones (both hands, both ankles, etc) • Generally worse in the morning or after long rest and lack of activity • Fatigue or tiredness

14. Treatments • Non-steroidal anti-inflammatory agents (NSAIDs) • Corticosteroids • Methotrexate • Hydroxychloroquine

15. Current Research • Bim is a critical molecule that orders immune cells to self-destruct after they “attack” • It was discovered that immune cells in RA are low in Bim • To correct this, an imitation of Bim was created, called BH3 mimetic • When BH3 mimetic was inserted into RA infected mice, the bad immune cells went “BOOM”

16. Our Solution • RASB (rheumatoid arthritis switch bot) • With be delivered through a patch • Will suck the rogue immune cells in, then switch them back to good, working immune cells, and spit them back out

17. Luekemia Leukemia is cancer of the blood and develops in the bone marrow. By Joshua E, Julie B, and Tyler M

18. Causes of Childhood Leukemia • X-rays increase risk of childhood Leukemia • Radiation: forms of energy • Chemicals like tungsten and arsenic • Viruses: a disease bug • Genetics: runs in the family

19. Treatments • Chemotherapy • Radiation treatment • Blood transfusions • Bone marrow • Transplant • Antibiotics

20. Symptoms • Fever • Shortness of breath • Fatigue • Frequent infections • Painless blue or purple lumps in the neck, underarm, stomach, or groin • Pain or feeling of fullness below the ribs • Paleness or pallor • Headaches • Easy bleeding or bruising • Loss of appetite • Tiny red spots under the skin • Bone or joint pain • Painless lumps that are sometimes around the eyes

21. Current Research • Micro RNA 125b causes multiple types leukemia • Too much Btk (Bruton-tyrosine-kinase) creates leukemia cells. • Cancer killing agent: (HDACI) histone deacetylase inhibitors

22. CKRS Attaches to RNA and switches it off Our Solution Propels through skin and body Senses Micro RNA125b CKRS Cancer Killing RNA Switch The CKRS (or cancer killing RNA switch) goes to the microRNA125b and switches it. It can also clone HDACI (or histone deacetylase inhibitor) to kill more leukemia cells. All this put together will cure childhood leukemia.

23. Idiopathic Scoliosis Scoliosis is a side-to-side curvature of the spine. By: Emily Hirsch, Madeline Stouffer, Sarah Weidenhofer

24. Causes • Hereditary • Occurs more often in girls than boys • A growth spurt • Occurs usually after age 10 • The back just doesn't grow as straight as it should and no one knows why

25. SYMPTOMS • Shoulders are different heights • Head is not centered directly above pelvis • Leaning of entire body to one side • Changes in the look or texture of skin overlying the spine (dimples, color changes)

26. Treatments • 25 degrees or less – no treatment • 25 – 30 degrees – brace • More than 45 degrees – surgery. If you have surgery your vertebrae will be fused together. • Treatments depend on how bad the curve will worsen A vertebrae

27. Facts • Everyone between 5th and 9th grade should get checked for scoliosis by their health care provider • It is important to be checked regularly if you have a family member with Idiopathic Scoliosis

28. Solution Our idea is to use carbon nano tubes and insert them into the body with the new robotic surgeon THE DaVINCI robot. The carbon nano tubes will form a protective shield around the spine. The protective shield will allow the spine to to move but will restrain from curving.