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Trifunctional Aminoamide Cellulose Derivative and its Characterization

Trifunctional Aminoamide Cellulose Derivative and its Characterization. Outline. Objectives Problem statement and motivation of the study Presuppositions from Literature Methodology. Objectives.

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Trifunctional Aminoamide Cellulose Derivative and its Characterization

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  1. Trifunctional Aminoamide Cellulose Derivative and its Characterization

  2. Outline • Objectives • Problem statement and motivation of the study • Presuppositions from Literature • Methodology

  3. Objectives • To illustrate how to use a couple of techniques to confirm the structural of a newly synthesized material and its intermediate. • To illustrate how to use a couple of techniques to characterize a final product and so provide some information for applications.

  4. Problem statement and motivation of the study • What are dendrimers? • “A dendrimer is a molecule with a form like the branches of a tree.”[1] • Dendrimers can be used in pharmaceutics, genetics, catalyst chemistry and superconductor currently or potentially. [2] [1] Wikipedia [2] Sand, Anders. Dendrimers and Their Technical Applicability

  5. Cellulose-based dendrimers Zhang, Changde et al. Biomacromolecules (2006), 7(1), 139-145.

  6.  Presuppositions from Literature • Narrow molecular weight distribution • The most exciting physical property of dendrimers is the variation of their intrinsic viscosities with molecular weight. [6] It is found that, when the generation increases beyond a certain point, the intrinsic viscosity begins to decline, contrary to the behavior of linear polymers (Fig.4). [6] http://www.dendritech.com/pamam.html

  7. Methodology • Using 1H to confirm the structural of intermediate product: • Using FT-IR to confirm and characterize the structural of CMCBA and CMCBADMPDA: • Using NMR to confirm and characterize the structural of CMCBA and CMCBADMPDA: • Using TGA to Characterize the Degree of Substitution of CMCBA and CMCBADMPDA: • Using Intrinsic Viscosity to characterize the conformation of CMCBADMPDA: • Using GPC-LS to characterize the MW and MWD of CMCBADMPDA:

  8. Using 1H to confirm the structural of intermediate product:

  9. Using FT-IR to confirm and characterize the structural

  10. Using NMR to confirm and characterize the structural of CMCBA and CMCBADMPDA:

  11. Using TGA to Characterize the Degree of Substitution

  12. Using Intrinsic Viscosity to characterize the conformation • CMC 5.62 dL/g, • CMCDMPDA 3.57 dL/g • CMCBADMPDA 0.39 dL/g

  13. Using GPC-LS to characterize the MW and MWD of CMCBADMPDA:

  14. Conclusions • The author got the “right ” product. • The product is of very low viscosity, which is suitable for drug delivery.

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