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Modeling the lower (motor) loop of the basal ganglia in movement

A preliminary model for the role of the basal ganglia in natural motor control and motor programming. MURI Meeting, June 4th, 2002 Steve Massaquoi, Zhi-Hong Mao, Eugene Lim, Munther Dahleh, and Eric Feron Massachusetts Institute of Technology.

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Modeling the lower (motor) loop of the basal ganglia in movement

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  1. A preliminary model for the role of the basal ganglia in natural motor control and motor programming MURI Meeting, June 4th, 2002Steve Massaquoi, Zhi-Hong Mao, Eugene Lim, Munther Dahleh, and Eric FeronMassachusetts Institute of Technology

  2. Modeling the lower (motor) loop of the basal ganglia in movement • Our model produced reasonable representations of normal and abnormal basal ganglionic functions in lower loop • Cruise movement generation • Dysfunctions in Parkinson’s disease and dystonia

  3. Basal ganglionic - cortical interaction Plant + - Movement + + Muscular-skeletal system Neuronal integrator 1 s Proposed role of the basal ganglia in regulating cruise movement velocity

  4. Model simulator structure

  5. Dysfunction of the basal ganglia in Parkinson’s disease • Signs of Parkinson’s disease • Tremor at rest • Slowness of movement (bradykinesia) • Rigidity of body

  6. Model simulator structure

  7. Dysfunction of the basal ganglia in dystonia • Signs of dystonia • Abnormal posture and tremor

  8. Model simulator structure

  9. Modeling the lower (motor) loop of the basal ganglia in movement • Our model produced reasonable representations of normal and abnormal basal ganglionic functions in lower loop • Cruise movement generation • Dysfunctions in Parkinson’s disease and dystonia

  10. Role of the higher (cognitive) loop of the basal ganglia in programmed behavioral tasks • Conflict resolution over access to limited cognitive resources • Switching, brain states transition, and sequence generation • Circuit in higher loop is the same as in lower loop • A toy example

  11. Conclusions and future work • Conclusions • The model is very simple • The model is consistent with the neuronal anatomy of the basal ganglia • The same circuit in the model is able to control cruise movement, to reproduce signs in the Parkinson’s disease and dystonia, and to execute programmed behavioral tasks • Future work • Self tuning (learning) through reinforcement • Learning cooperative behavior

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