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Case 2007-1971

Case 2007-1971. Ellen M Binder. Signalment & History. Number 200 18-month old female brown and white Boer goat Transported from NC to VA 1 week ago Bred within last 2-3 weeks Vaccinated within last week Other goats (4) normal Clinical Signs Lethargy, depression

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Case 2007-1971

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  1. Case 2007-1971 Ellen M Binder Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  2. Signalment & History • Number 200 • 18-month old female brown and white Boer goat • Transported from NC to VA 1 week ago • Bred within last 2-3 weeks • Vaccinated within last week • Other goats (4) normal • Clinical Signs • Lethargy, depression • Mucous membranes pale and grey • Pigmenturia • Neurologic Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  3. CBC & Chemistry • Anemia • Leukocytosis • Azotemia • Liver and muscle enzymes increased • Urinalysis • Proteinuria • Pigmenturia • Hematuria • Fecal Egg Count • Treatment Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  4. Differential Diagnoses • Copper Toxicosis • Infectious • Leptospira • Plant toxicosis • Unknown toxin/infection • Myopoathy Copper (serum): 2.6ppm Lead (blood): none detected Negative No methemoglobinemia Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  5. Kidney Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  6. Kidney: H&E (200x) Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  7. Kidney: H&E (400x) Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  8. Kidney: special stains Prussian Blue Halls Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only Steiner’s Rhodanine

  9. Kidney: Prussian Blue (+) Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  10. Liver: H&E (100x) Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  11. Liver: H&E (200x) Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  12. Liver: H&E (400x) Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  13. Liver: special stains Prussian Blue Halls Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only Rhodanine

  14. Liver: Halls (+) Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  15. Liver: Rhodanine (+) Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  16. Morphologic Diagnoses: • Kidney, acute tubular necrosis, diffuse, marked, with hemoglobin tubular casts and multifocal interstitial nephritis. • Liver, hepatitis, periportal and centrilobular, moderate, with copper accumulation, hepatocellular necrosis and cholestasis. Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  17. Copper Toxicosis Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  18. Copper Toxicosis • Stressor precipitates sudden release of Cu • Hepatic necrosis • Hemolytic crisis • Other species • Cattle • Pigs • Dogs: Bedlington, WHWT, & Skye terriers • Siamese cat (single case) • Humans (Wilson disease) Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  19. COPPER TOXICOSIS IN A DAIRY GOAT HERD. Cornish J, Angelos J, Puschner B, Miller G, George L., 2007 • 400 mixed breed dairy goats • Decrease in milk production and increased mortality rate • 9 deaths within a 1 month period • Clinical signs only in lactating goats • Anorexia, recumbency, neurologic abnormalities and death • AST, GGT and Total bilirubin: elevated • No evidence of hemolysis • Had been fed mineral mix containing 3,050 ppm copper for the past 9 months Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  20. Acknowledgments • Histology technicians • Co-authors: • Natalie Crawford, D Phillip Sponenberg, Rachel Tan, Flavia Lepene   References Adam SEI, Wasfi LA, Chronic copper toxicity in Nubian goats. J Comp Pathol 1977;87:623-627. Cornish J, Angelos J, Puschner B, Miller G, George L. Copper toxicosis in a dairy goat herd. JAVMA 2007; 231,4:586-589. Jubb, Kennedy & Palmer’s Pathology of Domestic Animals. Ed. M Grant Maxie. Saunders Ltd. 2:379-381. Solaiman SG, Maloney MA, Qureshi MA, et al. Effects of high copper supplements on performance, health, plasma copper and enzymes in goats. Small Rumin Res 2001;41:127-139. Soli NE, Nafstad I. Effects of daily oral administration of copper to goats. Acta Vet Scand 1978; 19:561-568. Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

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