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K27me1. K27me2. A687V EZH2. Y641N EZH2. A677G EZH2. K27me2. EZH2 WT. EZH2 WT. EZH2 WT.
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K27me1 K27me2 A687V EZH2 Y641N EZH2 A677G EZH2 K27me2 EZH2 WT EZH2 WT EZH2 WT Supp Figure 3. Biochemical activity of PRC2 complexes containing WT, A687V, Y641N, or A677G EZH2 using a library of 125 histone H3 peptides containing H3K27. Each peptide possesses up to five post-translational modifications, such as lysine and/or arginine methylation; lysine acetylation; or phosphorylation of serine, tyrosine, and/or threonine.