摘要

1. 臺灣常用民間用藥：紅田烏與黃花蜜菜對各種肝毒性物質所誘發急性肝障害之保護作用Hepatoprotective Effects of Taiwan Folk Medicine Alternanthera sessilis and Wedelia chinensis on Various Hepatotoxins-induced Acute Hepatotoxicity) • 為了探討二種台灣民間常用生藥， 旱蓮草 Eclipta prostrata（ Linn.）和蒲公英 Ixeris chinensis（Thunb.）Nak. 的保肝作用，本實 驗以三種不同作機轉的肝毒性物質，carbon tetrachloride，β-D- galacto- samine（GalN）和 Acetaminophen（ PcmL, i.e. paracetamol ）分別在大白鼠（GalN）和小白鼠（carbon tetrachloride & PcmL）上 誘發急性肝炎，再以生藥之熱水抽取物加以治療。藉由檢測實驗動物的 SGOT ，SGPT值以及肝臟病理切片的檢查，來觀察生藥的治療效果。由實 驗結果發現，蒲公英可以有效地抑制由carbon tetrachloride ， GalN及 PcmL等肝毒性物質引起的 SGOT，SGPT值的驟升，且顯著地改善此三種善 肝毒性物質所造成的組織病理學上的變化； 而旱蓮草也同樣地可以使 carbon tetrachloride 和 GalN 所引起的SGOT，SGPT值的上升統計上有 意義地下降，組織病理學上的傷害情形獲得改善， 但是對於PcmL引起的 肝傷害，雖然旱蓮草治療組的 SGOT，SGPT濃度值有較PcmL投與組的低， 但統計上並無意義，而且在病理切片的檢查方面，也並沒有看到明顯的治 療效果。和已被證實具有保肝作用的北柴胡（Bupleurum chinense DC.） 相比，蒲公英的治療效果與北柴胡相近，而旱蓮草則在對於 PcmL引起之 肝傷害的治療上，遜於北柴胡。

2. Abstract ： Hepatoprotective effects of Ixeris chinensis（ Thunb.）Nak. and Eclipta prostrata（ Linn. ）were studied on acute hepatitis induced in mice by a single dose of carbon tetrachloride （ 31.25μl/kg ,ip ）or acetaminophen （ 600 mg/kg i.p. ）and in rats by a single dose of β-D- galactosamine （ 188mg/kg, ip ）． Hepatoprotective activity was monitored by estimating the serum transaminases（ SGOT and SGPT ） levels and histopathological changes in the liver of experimental animals．The Ixeris chinensis（ Thunb. ） Nak. extracts significantly inhibited the acute elevation of serum transaminases caused by the three kinds of hepatotoxins. Histopathologically， the crude I. chinensis extracts significantly ameliorated the three hepatotoxins-induced histopathological changes in the livers of experimental animals. The Eclipta prostrata extracts significantly inhibited the acute elevation of serum transaminases induced by carbon tetrachloride in mice and byβ-D-GalN in rats. However, in the experimental model of acetaminophen, Although an inhibiting tendency was noticed in the E. prostrata treated group, but no significance could be observed. Histopathologically, the crude E. prostrata extracts significantly ameliorated either carbon tetrachloride or GalN- induced histopathological changes in the livers of experimental animals but no significant improvement could be observed in acetaminophen induced liver damage. All serological and histopathological effects of Eclipta prostrata and Ixeris chinensis were compared with those of Bupleurum chinense DC., which has been reported previously as a treatment criteria of hepatitis．