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A close look at Bion anotechnology MCCB October 21 2011 Thomas L. Deits, Ph.D .

A close look at Bion anotechnology MCCB October 21 2011 Thomas L. Deits, Ph.D . What is nanotechnology?. Any process or product that involves analysis or manipulation of materials at the nanometer scale. A thumbnail introduction to nanotechnology. Your fingernail is about as thick as.

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A close look at Bion anotechnology MCCB October 21 2011 Thomas L. Deits, Ph.D .

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  1. A close look at Bionanotechnology MCCB October 21 2011 Thomas L. Deits, Ph.D.

  2. What is nanotechnology? • Any process or product that involves analysis or manipulation of materials at the nanometer scale

  3. A thumbnail introduction to nanotechnology

  4. Your fingernail is about as thick as 500 E. coli, each of which is as thick as 500 1- nanometer slices

  5. E. coli with Pili and Flagella Ang L National University of Singapore http://www.icmm.csic.es/spmage07/spmageview.php?id=50

  6. Why is the nanometer scale important? Virtually every property of matter that we care about arises at the nanometer scale: Color Odor Strength Flexibility Conductivity Durability Biological activity

  7. Bionanotechnology • Biology happens • at the nanoscale: • DNA • enzymes • muscles • nerves • senses

  8. Biology is a Big Idea in Nanotechnology • Size and Scale • Structure of Matter • Forces and Interactions • Quantum Effects • Size-Dependent Properties • Self Assembly • Tools and Instrumentation • Models and Simulations • Science, Technology and Society The Big Ideas of Nanoscale Science and Engineering S.Y. Stevens et al. NSTA Press 209

  9. Capillary net of alveolae showing erythrocytes within the blood vessels. Oliver Meckes http://www.flickr.com/photos/fei_company/5679999618/in/set-2157626382741945

  10. Human beta-amyloid fibrils and oligomers" Prof. Francesco Mantegazza Universita' degli studi di Milano-Bicocca http://www.icmm.csic.es/spmage07/spmageview09.php?id=165

  11. Human malaria Infected red blood cells Dr. Li Ang Li http://www.icmm.csic.es/spmage07/spmageview09.php?id=30

  12. Bionanotechnology Tools and Instrumentation How do we work at the nanometer scale?

  13. Bionanotechnology Tools and Instrumentation How do we work at the nanometer scale? The Atomic Force Microscope A workhorse of nanotech

  14. Really… The Atomic Force Microscope

  15. How does it work? Pretty much like this….

  16. How does it work?

  17. What can it do? Mss.ElizavetaDrozd. A.V. Luikov Heat and Mass Transfer Institute (Belarus)  http://www.icmm.csic.es/spmage07/spmageview09.php?id=62

  18. Pre-metastasis cell aggregate INASMET-Tecnalia http://www.icmm.csic.es/spmage07/spmageview09.php?id=25

  19. Pyrococcus furiosus(archaea) http://www.sciencephoto.com/media/13219/enlarge

  20. And it’s not so hard to do these days…. www.nanosurf.com

  21. Bionanotechnology Forces and Interactions Examples from Physiology and Biotechnology

  22. Myosin walking visualized by AFM Kodera et. al Nature 468 72-76 (2010)

  23. Yeast bud scar Yves F. DufrêneJournal of Bacteriology, October 2002, p. 5205-5213, Vol. 184, No. 19

  24. High speed AFM Cellulase enzymes – traffic jams on the cellulose fiber Kiyohiko Igarashi, et al. Science 333, 1279 (2011)

  25. High speed AFM Cooperation between two types of cellulases Kiyohiko Igarashi, et al. Science 333, 1279 (2011)

  26. Bionanotechnology Tools and Instrumentation Manipulation at the nanoscale

  27. Nanotweezers http://www.amir.uni-oldenburg.de/en/37099.html

  28. Optical tweezers – nanoscale tools for biology P. Gross, et al. Nature Physics PUBLISHED ONLINE: 22 MAY 2011 |

  29. P. Gross, et al. Nature Physics PUBLISHED ONLINE: 22 MAY 2011 |

  30. Optical tweezers- There’s an app for that… R. W. Bowman, et al. J. Opt. 13 (2011)

  31. Bionanotechnology Self Assembly DNA Origami

  32. Toroidally supercoiled DNA Dr JozefAdamcik EcolePolytechnique Federale de Lausanne http://www.icmm.csic.es/spmage07/spmageview.php?id=153

  33. DNA Origami Depending on the sequence of DNA, the double helix can be bent or straight

  34. DNA Origami Using the simple rules of DNA pairing, bends can be introduced by design into a DNA molecule…

  35. DNA Origami …making it possible to design a shape that will assemble when the right pieces of DNA are mixed.

  36. DNA Origami DNA Origami in 3 dimensions! Han, et al. Science 332, 342 (2011)

  37. DNA Origami boxes (with lids) ES Andersenet al.Nature459, 73-76 (2009)

  38. Bionanotechnology Structure and Function The Lotus Leaf

  39. Abaxial side of a tomato leaf with trichomes. Adriaan van Aelst http://www.flickr.com/photos/fei_company/5636849589/in/photostream

  40. GE announces a thermal cooling system with twice the thermal conductivity of copper and a quarter of the weight using superhydrophobicity http://www.gereports.com/nanotech-breakthrough-keeps-computers-fast-by-tackling-heat/

  41. Forepart of a mite Margit Wallner Angelika Reichmann http://www.flickr.com/photos/fei_company/5886650891/in/set-72157626985240386

  42. Radiolarian LinneaRundgren http://www.flickr.com/photos/fei_company/5730242836/in/set-72157626382741945

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