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Chapter 5 Development and Plasticity of the Brain. Development of the Brain. Plasticity Nature versus Nurture Rapid development. Fig. 5-1, p. 122. Fig. 5-2, p. 123. Development of the Brain. The human central nervous system begins to form when the embryo is approximately 2 weeks old.
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Development of the Brain • Plasticity • Nature versus Nurture • Rapid development
Development of the Brain. • The human central nervous system begins to form when the embryo is approximately 2 weeks old.
Development of the Brain • The fluid-filled cavity becomes the central canal of the spinal cord and the four ventricles of the brain.
Development of the Brain • At birth, the human brain weighs approximately 350 grams. • By the first year. the brain weighs approximately 1000 grams. • The adult brain weighs 1200-1400 grams.
Development of the Brain • The development of neurons in the brain involves the following four processes: • Proliferation • Differentiation • Myelination • Synaptogenesis
Development of the Brain • Neurogenesis?? • Sperry’s (1954) research
Development of the Brain • Neural Darwinism • Neurotropin • Apoptosis • Nerve growth factor (NGF)
Development of the Brain • Fetal alcohol syndrome • Cocaine abuse • Enriched versus impoverished environments
Plasticity After Brain Damage • Survivors of brain damage show subtle to significant behavioral recovery. • Some of the mechanisms of recovery include those similar to the mechanisms of brain development such as the new branching of axons and dendrites.
Plasticity After Brain Damage • Possible causes of brain damage include: • Tumors • infections • exposure to toxic substances • degenerative diseases • closed head injuries.
Plasticity After Brain Damage • A closed head injury • A stroke or cerebrovascular accident • Ischemia • Hemorrhage • Edema-
How can we help? • tissue plasminogen activator (tPA) • Cooling the brain • Cannabanoids
Plasticity After Brain Damage • Diaschisis • Axonal regrowth • Collateral sprouts • Gangliosides • Progesterone
Plasticity After Brain Damage • Ways the brain compensates for decreased input and to restores normal functioning include: • Denervation supersensitivity • Disuse supersensitivity
Plasticity After Brain Damage • Phantom limb • Deafferenated limbs