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Comprehensive Guide to Acyl Chlorides: Preparation, Reactions, and Applications

Explore the preparation of acyl chlorides from carboxylic acids, reactions with nucleophiles, and conversion to carboxylic acids, esters, and amides. Learn about key synthesis methods and applications in organic chemistry.

kenyon-mcbride
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Comprehensive Guide to Acyl Chlorides: Preparation, Reactions, and Applications

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  1. Acyl chlorides

  2. Carboxylic acid RCOOH Acyl group RCO Acyl chloride RCOCl The acyl group Preparation of an acyl chloride • From carboxylic acid and thionyl chloride, SOCl2 Thionyl chloride Ethanoic acid Ethanoyl chloride

  3. Acyl chlorides in synthesis Acyl chlorides react with nucleophiles

  4. Acyl chlorides  Carboxylic acids and Esters Carboxylic acids using water Water Esters using alcohols Alcohol

  5. Acyl chlorides  Amides Primary amides using ammonia Ammonia Secondary amides using primary amines Primary amine

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