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Basic Translational Clinical

NIH Roadmap: A Systems Approach Across the Research Spectrum. Molecular Libraries. Clinical and Translational Science Awards. Basic Translational Clinical. {. Target ID & Valid. Screening/ Optimization. R & D. Preclinical. Phases I-III. Fundamental. Practice. New Pathways

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Basic Translational Clinical

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  1. NIH Roadmap: A Systems Approach Across the Research Spectrum Molecular Libraries Clinical and Translational Science Awards Basic Translational Clinical { Target ID & Valid. Screening/ Optimization R & D Preclinical Phases I-III Fundamental Practice New Pathways to Discovery Translational Cores Clinical Networks Research Teams of Future Harmonization Public-Private Partnerships PPP-Across the entire spectrum

  2. NIH Roadmap Molecular Libraries Program:Assay Development for High Throughput Screening http://nihroadmap.nih.gov/molecularlibraries/ Mark Scheideler, Ph.D., Program Director scheidelerm@ninds.nih.gov Fong Wang, Ph.D., Scientific Analyst wangf@ninds.nih.gov

  3. Aims of the Program: • Extract assays from ongoing research programs, and provide the resourcing needed to configure them for use in probe development projects. • Encourage the development of novel assays and assay technologies.

  4. Screening Centers Network Molecular Libraries Screening Center Network (MLSCN ) Compound Repository HTS Assays

  5. NMR-based methods Protein Kinases Protein-Protein interactions Enzymes Proteases Flow Cytometry High-throughput Microscopy Protein Translocation GPCRs High Content Screening Ion channels Transporters BSL-3 Overall Capabilities of the Screening Center Network Complementary HTS Kalypsys

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