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Referent Tracking in Electronic Health Records MIE 2005, Geneva

Referent Tracking in Electronic Health Records MIE 2005, Geneva. Dr. W. Ceusters European Centre for Ontological Research Saarland University, Saarbrücken - Germany. Barry Smith Institute for Ontology and Medical Information Science Saarland University, Saarbrücken - Germany. wisdom.

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Referent Tracking in Electronic Health Records MIE 2005, Geneva

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  1. Referent Tracking in Electronic Health RecordsMIE 2005, Geneva Dr. W. Ceusters European Centre for Ontological Research Saarland University, Saarbrücken - Germany Barry Smith Institute for Ontology and Medical Information Science Saarland University, Saarbrücken - Germany

  2. wisdom (- representation) knowledge - representation information - representation • Questions not often enough asked: • What part of our data corresponds with something out there in reality ? • What part of reality is not captured by our data, but should because it is relevant ? data - representation Reality What is there on the side of the patient Current mainstream thinking

  3. The story of Jane Smithan old case, well known in the literature ...

  4. Jane’s favourite supermarket The freezer section of Jane’s favourite supermarket The only available warning sign used outside A very suspiciously shaped upper leg July 4th, 1990: Jane goes shopping:

  5. A visit to the hospital City Health Centre Dr. Peters (City HC) Dr. Longley

  6. Diagnosis: a severe spiral fracture of the femur

  7. CityHC’s representation formalism(for statements in records) Categories: “represent concepts and are analogous to classes in other formalisms” Individuals: “concrete instances of categories which persist in space and time” Occurrences: “are specific occurrences of individuals and must be situated in space and time. The most important group of occurrences are observations — i.e. agents’ observations of individuals.” Rector AL, Nowlan WA, Kay S, Goble CA, Howkins TJ. A framework for modelling the electronic medical record. Methods Inf Med. 1993 Apr;32(2):109-19.

  8. Different patients. Same supermarket? Maybe the same (irrelevant ?) freezer section ? Or different supermarkets, but always in the freezer sections ? PtID Date ObsCode Narrative Same patient, same hypertension code: Same (numerically identical) hypertension ? 5572 5572 5572 2309 47804 5572 298 298 5572 5572 5572 21/03/1992 12/07/1990 22/08/1993 17/05/1993 01/04/1997 22/08/1993 01/04/1997 04/07/1990 03/04/1993 04/07/1990 12/07/1990 26442006 9001224 58298795 2909872 26442006 26442006 81134009 79001 9001224 79001 9001224 Accident in public building (supermarket) Closed fracture of radial head closed fracture of shaft of femur Essential hypertension Other lesion on other specified region closed fracture of shaft of femur Fracture, closed, spiral Essential hypertension closed fracture of shaft of femur Accident in public building (supermarket) Accident in public building (supermarket) 5572 04/07/1990 79001 Essential hypertension 0939 24/12/1991 255174002 benign polyp of biliary tract Same patient, different dates, same fracture codes: same (numerically identical) fracture ? 2309 21/03/1992 26442006 closed fracture of shaft of femur Same patient, same date, 2 different fracture codes: same (numerically identical) fracture ? Same patient, different dates, Different codes. Same (numerically identical) polyp ? Different patients, same fracture codes: Same (numerically identical) fracture ? 0939 20/12/1998 255087006 malignant polyp of biliary tract Registration through generic names But, there are some problems ...

  9. Main problem areasfor CityHC’s EHR • Statements refer only very implicitly to the concrete entities about which they give information. • Idiosyncracies of concept-based terminologies • tell us only that some instance of the class the codes refer to, is refered to in the statement, but not what instance precisely. • Are usually confused about classes and individuals. • “Country” and “Belgium”. • Mixing up the act of observation and the thing observed. • Mixing up statements and the entities these statements refer to.

  10. Consequences • Very difficult to: • Count the number of (numerically) different diseases • Bad statistics on incidence, prevalence, ... • Bad basis for health cost containment • Relate (numerically same or different) causal factors to disorders: • Dangerous public places (specific work floors, swimming pools), • dogs with rabies, • HIV contaminated blood from donors, • food from unhygienic source, ... • Hampers prevention • ...

  11. Proposed solution:Referent Tracking • Purpose: • explicitreference to the concrete individual entities relevant to the accurate description of each patient’s condition, therapies, outcomes, ... • Method: • Introduce an Instance Unique Identifier(IUI) for each relevant individual (= particular, = instance). • Distinguish between • IUI assignment: for instances that do exist • IUI reservation: for entities expected to come into existence in the future

  12. Ontology • ‘Ontology’: the study of being as a science • ‘An ontology’ is a representation of some pre-existing domain of realitywhich • (1) reflects the properties of the objects within its domain in such a waythat there obtains a systematic correlation between realityand the representation itself, • (2) is intelligible to a domain expert • (3) is formalized in a way that allows it to support automatic information processing • ‘ontological’ (as adjective): • Within an ontology. • Derived by applying the methodology of ontology • ...

  13. Universals EHR system City HC’s EHR system HC City HC Freezer section The freezer section of Jane’s favourite supermarket Jane Smith Person Dr. Peters Dr. Longley Femur Jane’s left femur Jane’s left femur Fracture Jane’s left femur fracture Image Jane’s fracture’s image Jane’s falling occurrents t Jane’s fracture as seen by Dr. Peters Jane’s fracture as seen by Dr. Longley Instances of Jane’s fracture Jane’s femur breaking Dr. Peter’s examination of Jane’s fracture Dr. Peter’s ordering of an X-ray Dr. Peter’s diagnosis making Jane’s fracture’s healing Shooting the pictures of Jane’s leg Dr. Longley’s examination of Jane’ s fracture Freezer section dismantled Jane dies An ontological analysis continuants

  14. Fracture Of Femur Severe Spiral Jane Smith’s Fracture Of Femur Jane Smith’s Fracture Of Femur’s severity Jane Smith’s Fracture Of Femur’s shape Jane Smith CityHC Dr. Peters City HC exists on 4th July 1990 Dr. Peters locatedat City HC on 4th July 1990 Ontological recategorisation Jane Smith’s consultation with Dr. Peters at City HC on 4th July 1990 Dr. Peters’ assessment of Jane Smith’s fracture of femur at City HC on 4th July 1990

  15. Essentials of Referent Tracking • Generation of universally unique identifiers; • deciding what particulars should receive a IUI; • finding out whether or not a particular has already been assigned a IUI (each particular should receive maximally one IUI); • using IUIs in the EHR, i.e. issues concerning the syntax and semantics of statements containing IUIs; • determining the truth values of statements in which IUIs are used; • correcting errors in the assignment of IUIs.

  16. IUI assignment • = an act carried out by the first ‘cognitive agent’ feeling the need to acknowledge the existence of a particular it has information about by labellingit with a UUID. • ‘cognitive agent’: • A person; • An organisation; • A device or software agent, e.g. • Bank note printer, • Image analysis software.

  17. Criteria for IUI assignment (1) • The particular’s existence must be determined: • Easy for persons in front of you, body parts, ... • Easy for ‘planned acts’: they do not exist before the plan is executed ! • Only the plan exists and possibly the statements made about the future execution of the plan • More difficult: subjective symptoms • But the statements the patient makes about them do exist ! • However: • no need to know what the particular exactly is, i.e. which universal it instantiates • No need to be able to point to it precisely • One bee out of a particular swarm that stung the patient, one pain out of a series of pain attacks that made the patient worried • But: this is not a matter of choice, not ‘any’ out of ...

  18. Criteria for IUI assignment (2) • The particular’s existence ‘may not already have been determined as the existence of something else’: • Morning star and evening star • Himalaya • Multiple sclerosis • May not have already been assigned a IUI. • It must be relevant to do so: • Personal decision, (scientific) community guideline, ... • Possibilities offered by the EHR system • If a IUI has been assigned by somebody, everybody else making statements about the particular should use it

  19. Fracture Of Femur Severe Spiral Jane Smith’s Fracture Of Femur Jane Smith’s Fracture Of Femur’s severity Jane Smith’s Fracture Of Femur’s shape Jane Smith CityHC Dr. Peters Jane Smith’s consultation with Dr. Peters at City HC on 4th July 1990 Dr. Peters’ assessment of Jane Smith’s fracture of femur at City HC on 4th July 1990 4th July 1990 Representation in the EHR particulars • Relevant particulars referred to using IUIs • Relationships that obtain between particulars at time t expressed using relations from an ontology (type OBO) • Statements describing for each particular, at time t: • Of what universal from an ontology it is an instance of • AND/OR (if one insists): • By means of what concept from a concept-based system it can sensibly be described

  20. Pragmatics of IUIs in EHRs • IUI assignment requires an additional effort • In principle no difference qua (or just a little bit more) effort compared to using directly codes from concept-based systems • A search for concept-codes is replaced by a search for the appropriate IUI using exactly the same mechanisms • Browsing • Code-finder software • Auto-coding software (CLEF NLP software Andrea Setzer) • With that IUI comes a wealth of already registered information • If for the same patient different IUIs apply, the user must make the decision which one is the one under scrutiny, or whether it is again a new instance • A transfert or reference mechanism makes the statements visible through the RTDB

  21. PtID Date ObsCode Narrative IUI-001 5572 5572 2309 5572 5572 5572 298 5572 298 5572 47804 03/04/1993 01/04/1997 04/07/1990 04/07/1990 12/07/1990 12/07/1990 21/03/1992 01/04/1997 17/05/1993 22/08/1993 22/08/1993 26442006 81134009 26442006 9001224 9001224 79001 58298795 79001 2909872 26442006 9001224 Accident in public building (supermarket) closed fracture of shaft of femur Other lesion on other specified region closed fracture of shaft of femur Essential hypertension Accident in public building (supermarket) Closed fracture of radial head Essential hypertension closed fracture of shaft of femur Fracture, closed, spiral Accident in public building (supermarket) IUI-001 IUI-001 IUI-007 5572 04/07/1990 79001 IUI-005 Essential hypertension 0939 24/12/1991 255174002 IUI-004 benign polyp of biliary tract 2309 21/03/1992 26442006 IUI-002 closed fracture of shaft of femur IUI-007 IUI-005 IUI-007 IUI-012 IUI-005 0939 20/12/1998 255087006 IUI-004 malignant polyp of biliary tract Advantage: betterreality representation IUI-003

  22. Other Advantages • mapping as by-product of tracking • Descriptions about the same particular using different ontologies/concept-based systems • Quality control of ontologies and concept-based systems • Systematic “inconsistent” descriptions in or cross terminologies may indicate poor definition of the respective terms

  23. Conclusion • Referent tracking can solve a number of problems in an elegant way. • Existing (or emerging) technologies can be used for the implementation. • Old technologies (concept-based systems) can play an interesting, but different role. • Big Brother feeling is to be expected but with adequate measures easy to fight. • The proof of the pudding is in the eating • Pilote is going to be set up

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