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Genetic epidemiology

Genetic epidemiology. Claire Infante-Rivard MD, PhD James McGill Professor. In the news: is it accurate information?. The heterogeneous A/G genotype was present in 29.5% of patients with VWF and 0.3% of the controls ( P <0.001), the researchers reported online in Clinical Epigenetics .

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Genetic epidemiology

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  1. Genetic epidemiology Claire Infante-Rivard MD, PhD James McGill Professor

  2. In the news: is it accurate information? • The heterogeneous A/G genotype was present in 29.5% of patients with VWF and 0.3% of the controls (P<0.001), the researchers reported online in Clinical Epigenetics. • "We therefore claim [that] genotype to be a risk factor for VWF, and that it may be used as a biological marker to facilitate the identification of risk populations who are being considered for exposure to potentially hazardous handheld vibrating machinery," they wrote. • "This may prevent thousands of employees from experiencing physical pain and disability, in addition to long-lasting administrative fights for VWF compensation, which frequently end unsettled and in great frustration • Voelter-Mahlknecht S, et al "Sirtuin 1 single nucleotide polymorphism (A2191G) is a diagnostic marker for vibration-induced white finger disease" Clin Epigenetics 2012.

  3. Areas of study • Small-for-gestational age babies • Lifestyle, biological, and genetic factors • Infante-Rivard C et al. New Engl J Med 2002; 347:19-24 • Infante-Rivard C. Am J Epidemiol 2010;171:999-1006. • Childhood leukemia • Environmental and genetic risk factors, lifestyle of parents; international consortium with the goal of pooling data • Infante-Rivard C et al. Am J Epidemiol 2007;165:1248-54 • Childhood brain tumors • Environmental and eventually genetic risk factors: international consortium in development • Roncarolo F, Infante-Rivard C. Cancer Causes and Control 2012;23:617-23. • Childhood asthma • Environmental and genetic risk factors • Infante-Rivard C et al. Am J Epidemiol 1999;150:528-31.

  4. More • Interest in family trios • How to use genetic data from both families and case-control together in the analysis • Infante-Rivard C, Mirea L, Bull SB Am J Epidemiol 2009;170:657-64 • The importance of transmission ratio distortion (transmission of alleles in trios) in control trios when analyzing case trios • Huang (PhD candidate), Labbe, Infante-Rivard

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