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Abstract:Excess respiratory symptoms and reductions in lung function in farmers and workers in swine confinement industry appear to be both atopic and non-atopic. In some workers, dysfunction may result early in occupational asthma. In other workers an acclimatization process appears to take place. Exposures to dust, ammonia and endotoxin are principle determinants of dysfunction. Mutations at the toll-like receptor 4 may protect against exposures. Management programs in the industry are indicated. Physiologic and GeneticDeterminants of Occupational Lung Dysfunction – Experience in the Swine Industry Friday, November 25, 2005, 12:00-1:00 RUH Mall Lecture Theatre COLLEGE OF MEDICINE SPEAKER’S FORUM Dr. James Dosman Director Institute of Agricultural Rural and Environmental Health (I.ARE.H) College of Medicine U of S Jim Dosman was the first Fergusson Professor of Respiratory Diseases, and is a past Distinguished Scholar of CIHR. Contacts for further information: Jim Thornhill, 966-8119 jim.thornhill@usask.ca Bernadine Rudichuk, 966-1417 bernadine.rudichuk@usask.ca