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S ystolic H eart failure treatment with the I f inhibitor ivabradine T rial

S ystolic H eart failure treatment with the I f inhibitor ivabradine T rial. The effect of heart rate reduction with ivabradine on renal function in patients with chronic heart failure: an analysis from SHIFT. Voors AA et al. Eur J Heart Fail. 2014 Feb 7. [ Epub ahead of print].

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S ystolic H eart failure treatment with the I f inhibitor ivabradine T rial

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  1. Systolic Heart failure treatment withthe Ifinhibitor ivabradine Trial The effect of heart rate reduction with ivabradine on renal function in patients with chronic heart failure: an analysis from SHIFT Voors AA et al. EurJ Heart Fail. 2014 Feb 7. [Epub ahead of print] www.shift-study.com

  2. 50 Placebo,renaldysfunction 40 Ivabradine,renal dysfunction 30 Patients (%) 20 10 0 0 6 12 18 24 30 Time (months) Effect of ivabradine on composite of CV death or HF hospitalization ] P=0.023 Placebo,norenaldysfunction ] P <0.001 Ivabradine,norenaldysfunction Voors AA et al. EurJ Heart Fail. 2014 Feb 7. [Epub ahead of print]

  3. Effect of ivabradine on other outcomes Voors AA et al. EurJ Heart Fail. 2014 Feb 7. [Epub ahead of print]

  4. Creatinine values over time with ivabradine and placebo 140 130 Placebo 120 Creatinine, μmol/L Ivabradine 110 100 90 80 70 Months 60 0 5 10 15 20 25 30 Voors AA et al. EurJ Heart Fail. 2014 Feb 7. [Epub ahead of print]

  5. Conclusions • In a large trial in patients with chronic systolic HF, renal function generally remained stable • However, if renal function worsened, it was strongly associated with an increased risk for events • Baseline heart rate was directly & independently associated with risk of worsening renal function • Treatment with ivabradine had a neutral effect on renal function during 2 years of follow-up • The beneficial prognostic effects and safety of ivabradine were similar in patients with and without renal dysfunction Voors AA et al. EurJ Heart Fail. 2014 Feb 7. [Epub ahead of print]

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