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COMPOSITION OF LIPIDS

Cholesterol. Protein. Triglyceride. Phospholipid. COMPOSITION OF LIPIDS. Lipoproteins Apolipoproteins. Chylomicron Very Low Density Lipoprotein Low Density Lipoprotein Intermediate Density Lipoprotein High Density Lipoprotein. CHOLESTEROL METABOLISM. Exogenous Endogenous

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COMPOSITION OF LIPIDS

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  1. Cholesterol • Protein • Triglyceride • Phospholipid COMPOSITION OF LIPIDS • Lipoproteins • Apolipoproteins

  2. Chylomicron • Very Low Density Lipoprotein • Low Density Lipoprotein • Intermediate Density Lipoprotein • High Density Lipoprotein

  3. CHOLESTEROL METABOLISM • Exogenous • Endogenous • Reverse Cholesterol Transport • LDL Uptake

  4. HMG CoA Reductase Inhibitors

  5. ↓ TG synthesis • ↓ lipoprotein synthesis • ↓ excretion of lipoproteins from liver; primarily VLDL • ↓ synthesis of cholesterol • ↑ production of sterols • ↑ HDL Fibric Acids

  6. Nicotinic Acid • Bind bile salts in gut • Cholesterol eliminated in the feces • Liver uses other sources of cholesterol (LDL) to make more bile Bile Acid Binding Resins

  7. Inhibits liver secretion of VLDL • Reduced serum LDL • Inhibits removal of HDL • Increases excretion of sterols in the feces Nicotinic Acid

  8. ↓ LDL • ↓ VLDL • ↓ TG HMG CoA Reductase Inhibitors • ↓ LDL • ↓ VLDL • ↓ TG Fibric Acids Nicotinic Acid • ↑ HDL Bile Acid Binding Resins • ↓ LDL

  9. TRIGLYCERIDES & TRAINING Decrease No Change Increase Numbers of Studies Dufaux, International Journal of Sports Medicine, 1982

  10. CHOLESTEROL & TRAINING Decrease Increase No Change Numbers of Studies Dufaux, International Journal of Sports Medicine, 1982

  11. LDL & TRAINING Decrease Increase No Change Numbers of Studies Dufaux, International Journal of Sports Medicine, 1982

  12. HDL & TRAINING Increase Decrease or No Change Numbers of Studies Dufaux, International Journal of Sports Medicine, 1982

  13. Pediatric Triglyceride response to Exercise Decrease No Change Increase Tolfrey K, et al Sports Medicine 29:99-112, 2000

  14. Pediatric Total Cholesterol response to Exercise Decrease Increase No Change Numbers of Studies Tolfrey K, et al Sports Medicine 29:99-112, 2000

  15. Pediatric LDL response to Exercise Decrease Increase No Change Numbers of Studies Tolfrey K, et al Sports Medicine 29:99-112, 2000

  16. Pediatric HDL response to Exercise Increase Decrease No Change Numbers of Studies Tolfrey K, et al Sports Medicine 29:99-112, 2000

  17. RESISTANCE TRAINING Hurley, B.F., MSSE 21:689-693, 1989.

  18. Hurley, B.F., MSSE 21:689-693, 1989.

  19. CHOLESTEROL & TRAINING Total Cholesterol Pre Post Whaley et al, J Cardiopulm Rehab 12:42-50, 1992

  20. Reduction in Risk related to Reduction in Cholesterol Lipid Research Clinics, JAMA 251:356-374, 1984.

  21. Risk reduction associated with a 20.7 mg/dL reduction in Total Cholesterol Lipid Research Clinics, JAMA 251:356-374, 1984.

  22. HDL Subfractions and Physical Activity Lehmann, R, et al. European J Clin Invest 31:37-44, 2001.

  23. HDL Subfractions and Physical Activity Lehmann, R, et al. European J Clin Invest 31:37-44, 2001.

  24. Exercise & Lipid Subfractions Kraus, WE, et al. N Eng J Med 347:1483-1492, 2002

  25. Exercise & Lipid Subfractions Kraus, WE, et al. N Eng J Med 347:1483-1492, 2002

  26. HDL Subfractions and Physical Activity Seip, RL. Et al. Arteriosclerosis and Thrombosis 13:1359-1367, 1993.

  27. HDL Subfractions and Physical Activity Seip, RL. Et al. Arteriosclerosis and Thrombosis 13:1359-1367, 1993.

  28. Lp(a) and Physical Activity Seip, RL. Et al. Arteriosclerosis and Thrombosis 13:1359-1367, 1993.

  29. How does HDL change with exercise? Lopez, A, et al Atherosclerosis 20:1-9, 1974.

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