1 / 3

LD and complex diseases: LD between a marker and the (unknown) genetic variant

LD and complex diseases: LD between a marker and the (unknown) genetic variant contributing to the disease underlies the association approach (i.e., comparing allele frequencies between cases and controls). And remember one can select tag-SNPs ….

kibo-petersen
Download Presentation

LD and complex diseases: LD between a marker and the (unknown) genetic variant

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. LD and complex diseases: LD between a marker and the (unknown) genetic variant contributing to the disease underlies the association approach (i.e., comparing allele frequencies between cases and controls)

  2. And remember one can select tag-SNPs… a. Short stretch of DNA for 4 different people – 3 SNPs are present b. Haplotypes made up of a combination of different alleles at 20 nearby SNPs c. Genotyping just 3 “tag” SNPs can distinguish all 4 haplotypes

  3. G A Diploid T C SNP1 SNP2 Haplotyping: Phase Problem Observed: SNP1 G/T SNP2 A/C Possible Haplotypes: GA, TC or GC, TA n SNPs  2n possible haplotypes

More Related