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Bertram et al. (2005) , NEJM, 352:884-894.

Bertram et al. (2005) , NEJM, 352:884-894. Bertram et al. (2005) , NEJM, 352:884-894. Bertram et al. (2005) , NEJM, 352:884-894. Bertram et al. (2005) , NEJM, 352:884-894. Ubiquilin 1 Gene (UBQLN1) Differential RNA splicing gives two different mRNA variants:. 10. 11. 11. 10. 1. 2. 3. 4.

kimberly-stephens
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Bertram et al. (2005) , NEJM, 352:884-894.

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  1. Bertram et al. (2005) , NEJM, 352:884-894.

  2. Bertram et al. (2005) , NEJM, 352:884-894.

  3. Bertram et al. (2005) , NEJM, 352:884-894.

  4. Bertram et al. (2005) , NEJM, 352:884-894.

  5. Ubiquilin 1 Gene (UBQLN1)Differential RNA splicing gives twodifferent mRNA variants: 10 11 11 10 1 2 3 4 5 6 7 9 2 3 4 5 6 7 9 1 8 Transcript Variant 1: All 11 exons Transcript Variant 2: Exon 8 excluded

  6. AD Cases have more mRNA variant 2 than Controls. AD Cases Controls Transcript Variant 1 Transcript Variant 2

  7. The C allele gives more “high risk”mRNA than the T allele Genotype CC(High Risk) Genotype TC(Medium Risk) Genotype TT(Low Risk) Transcript Variant 1 Transcript Variant 2

  8. Conclusion: • A C/T allele in the intron after exon 8 influences RNA splicing. • The C allele results in more transcript variant 2 than the T allele. • The more transcript 2, the greater the risk for Alzheimers.

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