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THE NERVOUS SYSTEM PART 1

THE NERVOUS SYSTEM PART 1. CHAPTER 11. Nervous System. Figure 11.1. Nervous System. The master controlling and communicating system of the body Functions Sensory input – monitoring stimuli occurring inside and outside the body Integration – interpretation of sensory input

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THE NERVOUS SYSTEM PART 1

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  1. THE NERVOUS SYSTEM PART 1 CHAPTER 11

  2. Nervous System Figure 11.1

  3. Nervous System • The master controlling and communicating system of the body • Functions • Sensory input – monitoring stimuli occurring inside and outside the body • Integration – interpretation of sensory input • Motor output – response to stimuli by activating effector organs

  4. Organization of the Nervous System • Central nervous system (CNS) • Brain and spinal cord • Integration and command center • Peripheral nervous system (PNS) • Paired spinal and cranial nerves • Carries messages to and from the spinal cord and brain

  5. Levels of Organization

  6. Peripheral Nervous System (PNS): Two Functional Divisions • Sensory (afferent) division • Sensory afferent fibers – carry impulses from skin, skeletal muscles, and joints to the brain • Visceral afferent fibers – transmit impulses from visceral organs to the brain • Motor (efferent) division • Transmits impulses from the CNS to effector organs

  7. Motor Division: Two Main Parts • Somatic nervous system • Conscious control of skeletal muscles • Autonomic nervous system (ANS) • Regulates smooth muscle, cardiac muscle, and glands • Divisions – sympathetic and parasympathetic

  8. Central Nervous System brain spinal cord EFFERENT AFFERENT sensory nerves axons of motor nerves somatic subdivision (motor functions) autonomic subdivision (visceral functions) para- sympathetic sympathetic Peripheral Nervous System

  9. Autonomic nervous system (ANS)

  10. Histology of Nerve Tissue • The two principal cell types of the nervous system are: • Neurons – excitable cells that transmit electrical signals • Supporting cells – cells that surround and wrap neurons

  11. Supporting Cells: Neuroglia • The supporting cells (neuroglia or glial cells): • Provide a supportive scaffolding for neurons • Segregate and insulate neurons • Guide young neurons to the proper connections • Promote health and growth

  12. Astrocytes • Most abundant, versatile, and highly branched glial cells • They cling to neurons and their synaptic endings, and cover capillaries • Functionally, they: • Support and brace neurons • Anchor neurons to their nutrient supplies • Guide migration of young neurons • Control the chemical environment

  13. Astrocytes Figure 11.3a

  14. Microglia and Ependymal Cells • Microglia – small, ovoid cells with spiny processes • Phagocytes that monitor the health of neurons • Ependymal cells – range in shape from squamous to columnar • They line the central cavities of the brain and spinal column

  15. Microglia and Ependymal Cells Figure 11.3b, c

  16. Oligodendrocytes, Schwann Cells, and Satellite Cells • Oligodendrocytes – branched cells that wrap CNS nerve fibers • Schwann cells (neurolemmocytes) – surround fibers of the PNS • Satellite cells surround neuron cell bodies with ganglia

  17. Oligodendrocytes, Schwann Cells, and Satellite Cells Figure 11.3d, e

  18. Neurons (Nerve Cells) • Structural units of the nervous system • Composed of a body, axon, and dendrites • Long-lived, amitotic, and have a high metabolic rate • Their plasma membrane functions in: • Electrical signaling • Cell-to-cell signaling during development

  19. blood vessels axon of one neuron many neurons bundled together inside a connective tissue sheath outer connective tissue of one nerve myelin sheath unsheathed node axon

  20. receptor endings cell body cell body axon ending peripheral axon cell body axon axon endings axon dendrites Sensory Neuron Interneuron Motor Neuron

  21. Neurons (Nerve Cells) Figure 11.4b

  22. Nerve Cell Body (Perikaryon or Soma) • Contains the nucleus and a nucleolus • Is the major biosynthetic center • Is the focal point for the outgrowth of neuronal processes • Has no centrioles (hence its amitotic nature) • Has well-developed Nissl bodies (rough ER) • Contains an axon hillock – cone-shaped area from which axons arise

  23. Processes • Armlike extensions from the soma • Called tracts in the CNS and nerves in the PNS • There are two types: axons and dendrites

  24. Dendrites of Motor Neurons • Short, tapering, and diffusely branched processes • They are the receptive, or input, regions of the neuron • Electrical signals are conveyed as graded potentials (not action potentials)

  25. Axons: Structure • Slender processes of uniform diameter arising from the hillock • Long axons are called nerve fibers • Usually there is only one unbranched axon per neuron • Rare branches, if present, are called axon collaterals • Axonal terminal – branched terminus of an axon

  26. Axons: Function • Generate and transmit action potentials • Secrete neurotransmitters from the axonal terminals • Movement along axons occurs in two ways • Anterograde — toward axonal terminal • Retrograde — away from axonal terminal

  27. Myelin Sheath • Whitish, fatty (protein-lipoid), segmented sheath around most long axons • It functions to: • Protect the axon • Electrically insulate fibers from one another • Increase the speed of nerve impulse transmission

  28. Myelin Sheath and Neurilemma: Formation • Formed by Schwann cells in the PNS • A Schwann cell: • Envelopes an axon in a trough • Encloses the axon with its plasma membrane • Has concentric layers of membrane that make up the myelin sheath • Neurilemma – remaining nucleus and cytoplasm of a Schwann cell

  29. Schwann cell

  30. Myelin Sheath and Neurilemma: Formation Figure 11.5a-c

  31. Nodes of Ranvier (Neurofibral Nodes) • Gaps in the myelin sheath between adjacent Schwann cells • They are the sites where axon collaterals can emerge

  32. Unmyelinated Axons • A Schwann cell surrounds nerve fibers but coiling does not take place • Schwann cells partially enclose 15 or more axons

  33. Amyotrophic Lateral Sclerosis ALS

  34. Axons of the CNS • Both myelinated and unmyelinated fibers are present • Myelin sheaths are formed by oligodendrocytes • Nodes of Ranvier are widely spaced • There is no neurilemma

  35. Regions of the Brain and Spinal Cord • White matter – dense collections of myelinated fibers • Gray matter – mostly soma and unmyelinated fibers

  36. Neuron Classification • Structural: • Multipolar — three or more processes • Bipolar — two processes (axon and dendrite) • Unipolar — single, short process

  37. Neuron Classification • Functional: • Sensory (afferent) — transmit impulses toward the CNS • Motor (efferent) — carry impulses away from the CNS • Interneurons (association neurons) — shuttle signals through CNS pathways

  38. Comparison of Structural Classes of Neurons Table 11.1.1

  39. Comparison of Structural Classes of Neurons Table 11.1.2

  40. Comparison of Structural Classes of Neurons Table 11.1.3

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