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A new Method For Targeting enveloped viruses

LJ-001. A new Method For Targeting enveloped viruses. Skeleton. Enveloped and Naked Viruses Modes of Infection LJ-001. Naked Viruses . Gary E. Kaiser . What are enveloped viruses?. Skeleton. Enveloped and Naked Viruses Modes of Infection LJ-001. Russell Kightley Media.

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A new Method For Targeting enveloped viruses

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  1. LJ-001 A new Method For Targeting enveloped viruses

  2. Skeleton • Enveloped and Naked Viruses • Modes of Infection • LJ-001

  3. Naked Viruses Gary E. Kaiser

  4. What are enveloped viruses?

  5. Skeleton • Enveloped and Naked Viruses • Modes of Infection • LJ-001

  6. Russell Kightley Media

  7. Excretory Pathways Naked Lytic cycle Exocytosis Enveloped Dan Stowell Botany Online Visual Resource Library

  8. Skeleton • Enveloped and Naked Viruses • Modes of Infection • LJ-001

  9. LJ001an aryl methyldienerhodanine derivative • A small anti-viral molecule effective against enveloped (but not naked) viruses. Wolf et. al.

  10. LJ001 acts on virus membranes in an irreversible manner Wolf et. al.

  11. Broad Spectrum • Influenza A • Filoviruses • Poxviruses • Arenaviruses • Bunyaviruses • Paramyxoviruses • Flaviviruses • HIV-1 • Hepatitis C • Ebola • And others

  12. Viruses lack a ‘biogenic’ membrane • Viruses can’t make their own proteins or repair their membrane like a cell can

  13. How?

  14. Russell Kightley Media

  15. Wolf et. al.

  16. How we would use this • Still very early in development, further testing needed • Shorten Viral Infection Course • Preventative Measure? • Could be put in condoms • New treatment for multiple viruses • Eliminate temporary infections • Fight Chronic ones • LJ001 is effective at very low doses • Potentially Excellent Therapeutic Index

  17. Sources (pictures not from papers) • Russell Kightley Media • Virco Online • Humanitarian Futures Programme • Gary E. Kaiser • HOPES (The Huntinton’s Disease Outreach Project for Education) at Stanford • Molecular Station

  18. Sources(papers) • Wolf et. al. A broad-spectrum antiviral targeting entry of enveloped viruses. Proc NatlAcadSci U S A. 2010 Feb 16;107(7):3157-62. Epub 2010 Jan 28. • Balzarini J. Targeting the glycans of glycoproteins: a novel paradigm for antiviral therapy. Nat Rev Microbiol. 2007 Aug;5(8):583-97. • Kudchodkar S., Levine, B. Viruses and Autophagy. Reviews in Medical Virology. 2009; 19: 359-378 • Melikyan GB. Common principles and intermediates of viral protein-mediated fusion: the HIV-1 paradigm.Retrovirology. 2008 Dec 10;5:111.

  19. Xkcd.com

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