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WNK1 Analysis: Protein Kinase Structure & Role in Hypertension

Explore WNK1 protein kinase structure, downstream targets, and roles in hypertension. Investigate mutations, protein interactions, and influence on ion homeostasis.

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WNK1 Analysis: Protein Kinase Structure & Role in Hypertension

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  1. WNK1: analysis of protein kinase structure, downstream targets, and potential roles in hypertension. Xu BE, Lee BH, Min X, Lenertz L, Heise CJ, Stippec S, Goldsmith EJ, Cobb MH. Cell Res. 2005 Jan

  2. WNKs – with no lysine (K) Arabidopsis thaliana – largest number of WNKs Mutations: WNK4 – coding point mutation WNK1 – intronic deletion

  3. Protein structure:

  4. A two-hybrid screen with the WNK1 Kinase domain suggests a potential mechanism to regulate membrane function • Brain c-DNA library yielded synaptotagmin 2 • Calcium sensor that facilitates fusion of vesicles with the plasma membrane • Interaction to calcium binding C2 domain

  5. These finds provide a biochemical mechanism that could lead to retention or insertion of proteins in the plasma membrane • Many ion transporters are regulated by membrane insertion or retrieval, WNK1 may influence ion homeostasis

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