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بسم الله الرحمن الرحيم

بسم الله الرحمن الرحيم. The relation between O 2 pressure and content: For dissolved O 2 it is linear. for oxygenated HB it is S- shaped or sigmoid shape. Normal O 2 HB dissociation curve. Shift of the curve to the right:

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بسم الله الرحمن الرحيم

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  1. بسم الله الرحمن الرحيم

  2. The relation between O2 pressure and content: • For dissolved O2 it is linear. • for oxygenated HB it is S- shaped or sigmoid shape.

  3. Normal O2 HB dissociation curve

  4. Shift of the curve to the right: Means that HB gives more O2 to the tissues even at a high PO2 (decreases affinity of HB to O2) as in increases of: • H+ (acidity). • PCO2. • 2-3 (DPG) diphosphoglyceride. • temperature. Therefore during exercise the curve is shifted to the right.

  5. Shift of the curve to the left Means that HB gives less oxygen to the tissues even under low pressure (increase affinity of HB to O2) as in: • decreases H+ (alkalosis). • decreases arterial PCO2. • decrease 2-3 DPG. • carbon monoxide poisoning.

  6. O2 HB dissociation curve during exercise

  7. Effect of exercise on respiratory mechanisms A- changes in ventilation “at the lung”: • PO2 in pulmonary capillaries falls from 40 to 25 mmHg. • blood flow /minute increased from 5.5-20L/min. • the total amount of O2 entering the blood increases from 250 ml/min. to 4000 ml/min. • the amount of CO2 removed increases from 200ml/min to 8000ml/min.

  8. B- changes at the tissue level: • during exercise PO2 at the tissue and venous blood may fall to zero. • more O2 diffuses to the tissues “ increases extraction ratio up to 95%” • capillary bed is dilated. • more CO2 added to the blood. “shift of O2 D. curve to the right”

  9. Fatigue: Inability to performs the exercise in spit of existence of the stimuli. causes: • depletion of the chemical transmitters • accumulation of metabolites. • depletion g muscle glycogen. • Ischemia. • accumulation of P. factor. • accumulation of tissue fluid in the muscle.

  10. Thank you

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