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PEPTIC ULCERS

PEPTIC ULCERS. Gastroenterology University of Pretoria Pretoria Academic Hospital Obedy Mwantembe 04 May, 2004. Definition – Peptic Ulcer. An ulcer in the Lower oesophagus Stomach Duodenum Duodenum Acute or Chronic. Ulcer or Erosion. Muscularis Mucosae Duodenal Ulcer

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PEPTIC ULCERS

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  1. PEPTIC ULCERS Gastroenterology University of Pretoria Pretoria Academic Hospital Obedy Mwantembe 04 May, 2004

  2. Definition – Peptic Ulcer • An ulcer in the • Lower oesophagus • Stomach • Duodenum • Duodenum • Acute or Chronic

  3. Ulcer or Erosion • Muscularis Mucosae • Duodenal Ulcer • Oesophageal ulcers • Small bowel ulcers

  4. Epideomiology • Up to 10-12% in one’s life time

  5. Duodenal Ulcer • Male:Female 5-2:1 • 90% H.pyroli

  6. Gastric Ulcer • Male:Female 2:1 • Up to 70% h. pyroli

  7. AETIOLOGY • Helicobacter Pyroli • Age 12 nearly 100% • Europe 30-40% • DU – 90% • GU – 70% • Non-Steroidal anti-inflammatory drugs (NSAIDs) • Inhibit cyclo-oxygenase activity • Reduce formation of protective PGE

  8. AETIOLOGY • Heredity • DU closer than GU especially if below 20y • Blood Group O • Smoking • GU than DU • Difficult healing • Stress ulcers

  9. AETIOLOGY • Acid-pepsin and acid • Vs • Defensive factors (Gastric mucosal barrier) • No ulcer No acid (Pernicious Anaemia) • Too much acid – severe ulcerations

  10. CHRONIC ULCER • 90% in lesser curve within antrum or at junction between body and antral mucosa (stomach) • Duodenal ulcers • 1st part • 50% anterior wall

  11. THE CLINIC • Recurrent abdominal pain • Epigastrium • Related to food • Episodic • History a questionable indicator of the presence of an ulcer

  12. Topics of Discussion • State the main ideas you’ll be talking about

  13. Topic One • Details about this topic • Supporting information and examples • How it relates to your audience

  14. Topic Two • Details about this topic • Supporting information and examples • How it relates to your audience

  15. Topic Three • Details about this topic • Supporting information and examples • How it relates to your audience

  16. Real Life • Give an example or real life anecdote • Sympathize with the audience’s situation if appropriate

  17. What This Means • Add a strong statement that summarizes how you feel or think about this topic • Summarize key points you want your audience to remember

  18. Next Steps • Summarize any actions required of your audience • Summarize any follow up action items required of you

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