1 / 20

h 2 = 0.9

La natura ereditaria dei caratteri multifattoriali si manifesta come aumento dell’incidenza del carattere fra I PARENTI di chi ha gia’ il carattere (probando). h 2 = 0.9. h 2 = 0.0. h 2 = 0.6. A. B. C. D. E. F. G. H. *CCTGCCA C CGGCTG. A. B. C. D. E. F. G. H.

kirsi
Download Presentation

h 2 = 0.9

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. La natura ereditaria dei caratteri multifattoriali si manifesta come aumento dell’incidenza del carattere fra I PARENTI di chi ha gia’ il carattere (probando)

  2. h2 = 0.9

  3. h2 = 0.0

  4. h2 = 0.6

  5. A B C D E F G H *CCTGCCACCGGCTG A B C D E F G H *CCTGCCAGCGGCTG

  6. rs859208 rs1043657 A B C D E F G H A B C D E F G H

  7. rs1043657 A G 6/188=0.032 (75x2+6+12)/ 188=0.894 G 174 a b rs859208 (12+1x2)= 0.074 0 14 C c d 188 6 182 rs859208 rs1043657 G/G; A/A G/G; A/G G/G; G/G G/C; A/A G/C; A/G G/C; G/G C/C; A/A C/C; A/G C/C; G/G G A 6 G G G G 75 G G C G 12 G G C G 1 C G 94

  8. [(a x d) - (b x c)] 2 = 0.0027 r2 = (a+c) (b+d) (a+b) (c+d) rs1043657 A G H0: a:d = b:c; a:b = d:c 6/188=0.032 (75x2+6+12)/ 188=0.894 0.926 G (a+b) a b rs859208 (12+1x2)/188= 0.074 0 0.074 D = (a x d) - (b x c) = .00237 C c d (c+d) D' = D/Dmax = 1 6/188=0.032 (14+168)/188= 0.968 (a+c) (b+d) 2 = r2 x N = 0.0027 x 188 = 0.508

  9. LINKAGE DISEQUILIBRIUMAssociazione NON CASUALEdi alleli A LOCI DIVERSIin cis

  10. r2 r2 r2 = 1 = 0.00 = 0.44 rsxxxxxxxx A A A G G G 0.16 0 0.40 0.24 0.40 0 0.40 0.40 0.40 G a a a b b b rsyyyyy 0.36 0.24 0.20 0.60 0.40 0 0.60 0.60 0.60 C c c c d d d 0.40 0.60 0.40 0.60 0.40 0.60 (a+c) (b+d) (a+c) (b+d) (a+c) (b+d) D = .24 D = .00 D = -0.16 D' = D/Dmax = 1 D' = D/Dmax = 0 D' = D/Dmax = 1 G-A C-G G-A G-G C-A C-G G-G C-A C-G

  11. r2 r2 = 0.00 = 0.44 rsxxxxxxxx A A G G 0.10 0 0.30 0.40 0.40 0.40 G a a b b rsyyyyy 0.50 0.10 0.40 0.20 0.60 0.60 C c c d d 0.20 0.80 0.20 0.80 (a+c) (b+d) (a+c) (b+d) D = .02 D = -0.08 D' = D/Dmax = 0 D' = D/Dmax = 1 G-A G-G C-A C-G G-G C-A C-G

  12. DEDUZIONE DELLO STATO ANCESTRALE H.sapiens Clint (Pan troglodytes) A A, G Ho: Uguali per discesa cioe' ancestrale

  13. C G 5' ala gln G A 5' thr his G G 5' ala his APLOTIPI INDIVIDUATI FILOGENESI rs1043657 rs859208 Africa Eurasia occ. In- e out-of-Africa Mut. G>A in rs1043657 Mut. C>G in rs859208

More Related