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*Adjusted for age, sex, HbA 1c , serum lipids, BMI, smoking, alcohol use, and study drug

ADVANCE Renal Events by Systolic BP Achieved During Follow-up*. 10. 9. P for trend <0.0001. 8. 7. Annual patient event rate (%). 6. Relative risk reduction per 10 mmHg lower systolic BP: 6.8% (95% CI: 4.6-9.0%), P <0.0001. 5. 4. 100. 110. 130. 140. 150. 160. 120.

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*Adjusted for age, sex, HbA 1c , serum lipids, BMI, smoking, alcohol use, and study drug

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  1. ADVANCE Renal Events by Systolic BP Achieved During Follow-up* 10 9 P for trend <0.0001 8 7 Annual patient event rate (%) 6 Relative risk reduction per 10 mmHg lower systolic BP: 6.8% (95% CI: 4.6-9.0%), P<0.0001 5 4 100 110 130 140 150 160 120 Median diastolic BP 106 116 125 135 144 154 168 1431 4266 8974 11983 9138 4942 3470 No. of person-years Achieved systolic blood pressure (mmHg) *Adjusted for age, sex, HbA1c, serum lipids, BMI, smoking, alcohol use, and study drug Adapted from Bulpitt C. ESH 2008.

  2. HYVET: Analysis of Total Mortality andCV Events in Predefined Subgroups

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