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bb. Outlasts,Outperforms,Outnumbers™. Also Sprach Zarathustra-Eumir Deodato, Prelude. Table of Contents. The Silverlon ® Advantage slide 3 The Negative Pressure Innovation slides 4-5 What Silverlon® Has slides 6-7 How To Use slides 8-10

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  1. bb Outlasts,Outperforms,Outnumbers™ Also Sprach Zarathustra-Eumir Deodato, Prelude

  2. Table of Contents • The Silverlon® Advantage slide 3 • The Negative Pressure Innovation slides 4-5 • What Silverlon® Has slides 6-7 • How To Use slides 8-10 • Five Case Studies slides 11-22 • 90 Day Value Analysis slide 23-24 • One Year Value Analysis Projection slides 25-27 • Savings Calculator – hospital slide 28 • Savings Calculator – home health slide 29 • Contact Information slide 30

  3. The Silverlon® Advantage • Silverlon® is the most cost effective silver product on the market and is the most versatile. • Silverlon® can be rinsed to remove excess exudate and reapplied for up to 7 day use.

  4. Silverlon® Negative Pressure DressingsAward Winning Innovation Combine Silverlon® NPD with NPWT Accelerates Healing Potential. Proven inover 300 patient trials to enhance and accelerate granulation and wound closure by 20% to 40% vs. Conventional protocols. Reduces Overall Cost of NPWT. Wounds heal quicker, saving rental charges, kit costs, and nursing time. Lowers Infection. Proven in over 300 patient trials to lower the risk of the media re-infecting the wound bed.

  5. Silverlon® Negative Pressure DressingsAward Winning Innovation Combine Silverlon® NPD with NPWT: (Continued) Reduces Foam Sticking to the Wound. Silverlon® not only reduces the incidence of foam adhering to the granulation bed, but it also eliminates the need to pick the foam out of the wound. Safe and Easy to Use. Silverlon® is not known to interact with any drug and is bactericidal to all clinically relevant pathogens. It will not shed metallic silver into tissue, nor will it tattoo or stain the skin.

  6. Silverlon® Negative Pressure DressingsClinical Investigations

  7. Silverlon® Negative Pressure DressingsSustained Strength & Easy to Use

  8. Silverlon®Negative Pressure DressingsSimpleTechnique Means Easy to Use

  9. Silverlon® Negative Pressure Dressings Professional Guidelines For Use • Moisten dressing with sterile or clean water. Saline may be used for irrigation, but should be avoided as the primary wetting agent. • Apply either side of dressing in direct contact with wound bed and walls, and overlap wound edges onto healthy skin. • Cover Silverlon® NPD with negative pressure foam or fill media ( if using Versatile 1) and drape per manufacturer’s instructions. • Change Silverlon® NPD when you change foam or fill media. • Silverlon® NPD may be used for up to 7 days.

  10. Silverlon® Negative Pressure Dressings Frequently Asked Questions • Can these dressings handle highly exudative wounds ? • The unique dual “flow ports” allow for rapid fluid passage into the media, making it an ideal dressing over highly exudative wounds, with or without the use of NPWT. • Can these dressings be rinsed and reused ? • Based on professional discretion, all these dressings may be rinsed and reused, provided they are substantially free of debris and exudate. • Can these dressings also be used without negative pressure therapy ? Absolutely, simply follow Silverlon® wound contact protocol. • See dressing package for Indications and Caution.

  11. Five Clinical CasesCombining Negative Pressure Therapy with Silverlon® Negative Pressure Dressings, and Bilayered Living Skin Equivalent

  12. Case Study 1 • 82 y/o woman with diabetes, peripheral vascular disease, and neuropathy • Ulcer developed from thermal injury (electric blanket). Failed to respond to conventional treatment.

  13. Case Study 1(Continued) 1/12/02 Necrotic Diabetic Heel Ulcer 5.1 x 7.0cm 1/12/02 s/p debridement, pre-Apligraft®, Silverlon®, KCI Wound Vac®

  14. Case Study 1(Continued)85% Wound Volume Reduction in 90 days 1/14/02 2 days s/p Apligraft®, Silverlon®, Wound Vac® 4/10/02 2 days s/p 2nd apligraft®, Silverlon®, Wound Vac® 2.1 x 2.0cm

  15. Case Study 2Rapid Healing in 90 days 10/3/01 Admit 4.7 x 6.0 x 1.8cm 12/31/01 Healed at 3 months

  16. Case Study 3Rapid Healing In 30 Days 12/10/01 s/p Silverlon®, Vac®, & Apligraft® 0.6 x 1.0 cm 11/12/01 Silverlon® & Wound Vac® 4.0 x 4.7 x 0.7 cm

  17. Case Study 4 • 73 y/o woman with chronic steroid dependent asthma, hypertension bilateral venous stasis disease and hx of phlebitis. • 3 month old painful leg wound that originated from an insect bite and has failed conventional therapy

  18. Case Study 4 (Continued) Admit s/p debridement s/p 12 of Wound Vac® 6/11/01 application of Apligraf® continue Vac® and Silverlon® reduced pain

  19. Case Study 4 (Continued) 7/2/01 s/p Apligraf® & Vac Continue Silverlon® and Dynaflex® 8/28/01 Healed in less than 3 months

  20. Case Study 5 • 63 y/o woman with chronic steroid dependent rheumatoid arthritis, Sjogren Syndrome, osteoporosis and iron deficiency anemia present with a a traumatic painful leg Ulcer.

  21. Case Study 5 (Continued) 11/26/01 Admit 9.9 x 8.5cm 11/29/01 s/p debridement application Apligraf®

  22. Case Study 5(Continued) 12/03/01 1st dressing change, reduced pain, went on to rapid healing 11/29/01 Apligraf®, Silverlon®, Vac®

  23. COMPARATIVE STUDY OF COMBINATION THERAPYSILVERLON®NPD with VAC® VS. VAC® ALONE Non-Healing Chronic Wounds Associated With Tissue Defects of the Legs and Feet, Stanley N. Carson, M.D.; Fountain Valley Regional Hospital. Presented at SAWC, 2005 Efficacy and Cost Savings Analysis at 90 days of Treatment. Patient Population VAC® Alone N=40 Silverlon® NPD & VAC® N=40 Age 16 – 90 years 15 – 89 years Male 21 21 Female 19 19 Diabetes 18 18 Tobacco Use 7 7 Renal Failure 5 5 Ischemia ABI 0.5-0.8 12 12 Wound Areas Avg. = 10cc Avg. = 12cc

  24. COMPARATIVE STUDY OF COMBINATION THERAPYSILVERLON®NPD with VAC® VS. VAC® ALONE (Continued) RESULTSVAC® AloneSilverlon® NPD & VAC® Percent healed at 90 days 50% 87.5% Infection 15% 0 No. of kits/patient 30 18 Nurse time/ patient 17.5 hrs. 10.5 hrs. Savings per patient w/ Silverlon® NPD - $ 3,073.50 __________________________________________________________________ Protocol: VAC® alone: VAC® dressings changed every 3 days. Silverlon® & VAC®: VAC® dressings changed every 5 days.

  25. One Year Value Analysis Projection Using Silverlon® withNegative Pressure Wound Therapy • Expected Annual Cost Savings Analysis Using Medicare Reimbursement Pricing • 2003 actual utilization at 800 bed teaching hospital with an average of 18 active VAC’s • Silverlon® Negative Pressure Dressing with VAC® vs. VAC® with Standard Kit

  26. One Year Value Analysis ProjectionNegative Pressure Wound Therapy(Continued) VAC® Alone --- Standard KCI Protocol 3 Dressing Changes Per Week Costs Actual NPT Patient Days - 2003 6,570 Actual Rental Charge (Per Day Per Machine) $ 70.00 $ 459,900 Actual Kit Usage - 3 kits/wk/patient (total units) 2,190 Avg.Kit Cost (foam/drape) – avg. of all sizes $ 28.00 $ 61,320 Avg. Nursing Time Per Kit Change - 38 min. each 1,387hrs. @ $ 27/hr $ 37,449 Avg. Infection Rate: NPT Related 12% Total $558,669 VAC® Combined with Silverlon® NPD --- Silverlon® Protocol 1 Dressing Change Per Week Costs Est. NPT Patient Days with Silverlon® - 2003 5,256 Est. NPT Rental Charge (Per Day Per Machine) $ 70.00 $ 367,920 Est. Kit Usage – 1 kit/wk/patient (total units) 938 Avg. Kit Cost $ 28.00 $ 26,264 Avg. Nursing Time for 938 kits @ 38 min. each 594 hrs. @ $27/hr $ 21,411 Total $ 415,595 Expected Savings: $ 558,669 - $ 415,595 = $ 143,074 or 25 %

  27. One Year Value Analysis Projection Negative Pressure Wound Therapy(Continued) Expected Annual Savings Rental Savingsfrom fewer rental days needed: $ 459,900 - $ 367,920 = $ 91,980 or 20% Disposable Kit Savings from fewer kits used: 2,190 – 938 = 1,254 saved $ 35,056 or 57% Nursing Time Savings from fewer kit changes: 1,254 kits @ 38 minutes = 793 hrs. or 57% Payroll Dollars Saved: (793 nurse hours x $ 27 avg.) = $ 21,411 OverallExpected Annual Savings: $ 143,074 or 25% Can your silver dressing do this ?

  28. Savings Calculator – Hospital(file on this CD as NPD Savings Calculator – Hospital.xls)

  29. Savings Calculator – Home Health( file on this CD as NPD Savings Calculator – Home Health.xls)

  30. Silverlon®ContactInformation Argentum Medical, LLC. (Customer Service) 1-888-551-0188 More information is available at SILVERLON.COM Silverlon® Outlasts, Outperforms, Outnumbers™

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