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Neuroendocrinology

Neuroendocrinology. Neurons + Hormones  Behavior . R eleasing sites inside the central nervous system Hypothalamus neurotransmitters, neuropeptides Neurosecretory factors released into bloodstream Pituitary gland n eurosecretory factors

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Neuroendocrinology

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  1. Neuroendocrinology

  2. Neurons + Hormones  Behavior • Releasing sites inside the central nervous system • Hypothalamus • neurotransmitters, neuropeptides • Neurosecretory factors released into bloodstream • Pituitary gland • neurosecretory factors • Target sites outside the central nervous system • Major organs • hormones

  3. Neurons and HPO Axis(hypothalamic-pituitary-organ)

  4. Broad Signaling

  5. Hypothalamus

  6. Neurotransmitters and Neuropeptides

  7. Neuropeptide Y

  8. Pituitary Gland

  9. Neurosecretory Factors • Two types • short route: signal originates in posterior pituitary (eg. oxytocin, vasopressin) • long route: signaling originates in hypothalamus, synapses in anterior pituitary (eg. everything else)

  10. Long Route Hypothalamus  Median Eminence  Hypophyseal Portal  Pituitary

  11. Median Eminence

  12. Anterior Pituitary

  13. Organs

  14. Examples

  15. Hormones • Two types • Steroidal: binding sites in cell nucleus • Non-steroidal:binding sites on cell surface

  16. Steroids derive from cholesterol

  17. Steroids can alter DNA transcription

  18. Steroids alter brain structure and behavior

  19. Hormones and annual reproductive cycles

  20. Environmental impact

  21. How did we get here?

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